1403473-09-5

Basic information

• Product Name: N-[3-(3-aminobenzyl)-2,4-dioxoimidazolidin-1-yl]-5-phenyl-2-furamide hydrochloride
• Synonyms: N-[3-(3-aminobenzyl)-2,4-dioxoimidazolidin-1-yl]-5-phenyl-2-furamide hydrochloride
• CAS NO: 1403473-09-5
• Molecular Weight: 426.859
• Mol File: 1403473-09-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-[3-(3-aminobenzyl)-2,4-dioxoimidazolidin-1-yl]-5-phenyl-2-furamide hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: N-[3-(3-aminobenzyl)-2,4-dioxoimidazolidin-1-yl]-5-phenyl-2-furamide hydrochloride(1403473-09-5)
• EPA Substance Registry System: N-[3-(3-aminobenzyl)-2,4-dioxoimidazolidin-1-yl]-5-phenyl-2-furamide hydrochloride(1403473-09-5)

Safety Data

• Hazardous Substances Data: 1403473-09-5(Hazardous Substances Data)

Upstream product

• 1403473-71-1 5-phenyl-N-(2,4-dioxoimidazolidin-1-yl)-2-furamide 
• 52938-97-3 5-phenylfuran-2-carboxylic acid 
• 108-86-1 bromobenzene 
• 13803-39-9 5-phenylfuran-2-carbaldehyde 
• 27329-70-0 5-formylfurane-2-boronic acid 
• 1403473-77-7 N-{3-[3-(tert-butoxycarbonylamino)benzyl]-2,4-dioxoimidazolidin-1-yl}-5-phenyl-2-furamide 

Relevant articles and documents

Small-molecular inhibitors of Ca2+-induced mitochondrial permeability transition (MPT) derived from muscle relaxant dantrolene

A structure consisting of substituted hydantoin linked to a 5-(halophenyl)furan-2-yl group via an amide bond was identified as a promising scaffold for development of low-molecular-weight therapeutic agents to treat vascular dysfunction, including ischemia/reperfusion injury. Among the compounds synthesized, 5-(3,5-dichlorophenyl)-N-{2,4-dioxo-3-[(pyridin-3-yl)methyl] imidazolidin-1-yl}-2-furamide (17) possessed the most potent inhibitory activity against Ca2+-induced mitochondrial swelling. The structural development, synthesis and structure-activity relationship of these compounds are described.