1403589-41-2

Upstream product

• 365547-91-7 ethyl 2-amino-5-chloro-1H-indole-3-carboxylate 
• 1403589-25-2 6-chloro-3H-pyrimido[4,5-b]indol-4(9H)-one 
• 1221177-84-9 4,6-dichloro-9H-pyrimido[4,5-b]indole 
• 1374429-99-8 4,6-dichloro-9-(2,3,5-tri-O-benzoyl-β-d-ribofuranosyl)-pyrimido[4,5-b]indole 
• 1403589-27-4 6-chloro-4-(furan-2-yl)-9-(2,3,5-tri-O-benzoyl-β-d-ribofuranosyl)-9H-pyrimido[4,5-b]indole 
• 118486-94-5 2-(tributylstannyl)furan 
• 55552-70-0 furan-3-boronic acid 
• 62567-91-3 ethyl 2-(5-chloro-2-nitrophenyl)-2-cyanoacetate 
• 611-06-3 2,4-dichloronitrobenzene 

Relevant academic research and scientific papers

Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides

A series of new pyrimido[4,5-b]indole ribonucleosides bearing phenyl or hetaryl group at position 4 has been prepared by selective Pd-catalyzed cross-coupling reactions of the corresponding protected 4,6-dichloropyrimido[4, 5-b]indole ribonucleoside with (het)arylboronic acids or stannanes followed by deprotection. Further cross-couplings under harsher conditions and employing X-Phos ligand proceeded at the position 6 leading to 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides. Some of these compounds displayed antiviral activity against Dengue virus.