1403597-77-2

Upstream product

• 294190-18-4 methyl 3-amino-5-chloro-2-methylbenzoate 
• 179321-49-4 N-(tert-butoxycarbonyl)-4-aminocyclohexanone 
• 294190-17-3 methyl 5-chloro-2-methyl-3-nitrobenzoate 
• 154257-81-5 5-chloro-2-methyl-3-nitrobenzoic acid 
• 7499-06-1 5-chloro-2-methylbenzoic acid 

Downstream Products

• 1403596-80-4 methyl 3-(((trans)-4-((tert-butoxycarbonyl) amino)cyclohexyl)(ethyl)amino)-5-chloro-2-methylbenzoate 
• 1403596-81-5 C₂₁H₃₁ClN₂O₄ 
• 1403596-82-6 3-(((1r,4r)-4-aminocyclohexyl)(ethyl)amino)-5-chloro-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methylbenzamide 
• 1617501-29-7 tert-butyl ((trans)-4-((5-chloro-3-(((2,6-dimethyl-4-oxo-4H-pyran-3-yl)methyl)carbamoyl)-2-methylphenyl)(ethyl)amino)cyclohexyl)carbamate 

Relevant academic research and scientific papers

SUBSTITUTED BENZENE COMPOUNDS

The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

ENHANCER OF ZESTE HOMOLOG 2 INHIBITORS

This invention relates to novel compounds according to Formula (I) which are inhibitors of Enhancer of Zeste Homolog 2 (EZH2), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of cancers. Epigenetic modifications play an important role in the regulation of many cellular processes including cell proliferation, differentiation, and cell survival. Global epigenetic modifications are common in cancer, and include global changes in DNA and/or histone methylation, dysregulation of non-coding RNAs and nucleosome remodeling leading to aberrant activation or inactivation of oncogenes, tumor suppressors and signaling pathways.

SUBSTITUTED BENZENE COMPOUNDS

The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.