140360-37-8

Basic information

• Product Name: 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-5-methoxytetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione (non-preferred name)
• Synonyms: 4'-Methoxythymidine
• CAS NO: 140360-37-8
• Molecular Formula: C₁₁H₁₆N₂O₆
• Molecular Weight: 272.2545
• Mol File: 140360-37-8.mol
• Article Data: 3

Chemical Properties

• Density: 1.48g/cm³
• Refractive Index: 1.6
• CAS DataBase Reference: 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-5-methoxytetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione (non-preferred name)(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-5-methoxytetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione (non-preferred name)(140360-37-8)
• EPA Substance Registry System: 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-5-methoxytetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione (non-preferred name)(140360-37-8)

Safety Data

• Hazardous Substances Data: 140360-37-8(Hazardous Substances Data)

Usage

Chemical structure

The compound consists of a pyrimidine-2,4(1H,3H)-dione ring linked to a tetrahydrofuran ring with a hydroxy, hydroxymethyl, and methoxy substituent.

Stereochemistry

The compound has a specific stereochemistry with the R,S configuration at the 2nd, 4th, and 5th carbon atoms of the tetrahydrofuran ring (2R,4S,5R).

Functional groups

The compound contains a hydroxy (-OH) group, a hydroxymethyl (-CH2OH) group, a methoxy (-OCH3) group, and a methyl (-CH3) group.

Pyrimidine ring

The compound has a pyrimidine-2,4(1H,3H)-dione ring, which is a six-membered nitrogen-containing heterocycle with two carbonyl groups at the 2nd and 4th positions.

Tetrahydrofuran ring

The compound also contains a tetrahydrofuran ring, which is a five-membered oxygen-containing heterocycle with four carbon atoms and one oxygen atom.

Methyl group

A methyl group is attached to the pyrimidine ring, which can influence the compound's properties and reactivity.

Potential applications

The compound may have various applications in pharmaceuticals, agriculture, or other industrial uses, depending on its specific structure and characteristics.

Solubility

The solubility of the compound in different solvents (e.g., water, organic solvents) would depend on its specific structure and functional groups.

Stability

The stability of the compound under various conditions (e.g., temperature, pH, light exposure) would also depend on its specific structure and functional groups.

Upstream product

• 83467-48-5 1-[(2R,4S,5R)-4-(tert-butyldiphenylsilanyloxy)-5-hydroxymethyltetrahydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 146604-43-5 1-(2-deoxy-3-O-tert-butyldiphenylsilyl-β-D-erythro-pentadialdo-1,4-furanosyl)-5-methyluracil 
• 50-89-5 thymidine 
• 25953-14-4 1-((2R,4S,5S)-4-hydroxy-5-(iodomethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione 
• 67-56-1 methanol 
• 28034-72-2 1-((2R,4S)-4-hydroxy-5-methylenetetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione 

Relevant articles and documents

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Purine and pyrimidine 4′-alkoxy-2′-deoxynucleosides were efficiently prepared from nucleoside 4′-5′-enol acetates in three steps by N-iodosuccinimide promoted alkoxylation, hydrolysis, and reduction followed by conversion to phosphoramidite monomers for t

Synthesis and anti-HIV activity of 4'-azido- and 4'-methoxynucleosides

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