1403608-12-7

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 154491-89-1 (R)-3-(tert-butyl-diphenyl-silanyloxy)-butan-1-ol 
• 147963-63-1 ethyl (R)-3-(tert-butyldiphenylsilyloxy)butyrate 
• 1206620-80-5 tert-butyl-[(R)-3-(4-methoxy-benzyloxy)-1-methylpropoxy]-diphenyl-silane 

Downstream Products

• 1403608-18-3 (4S,5S)-4-[(R,E)-4-tert-butyldiphenylsilyloxypent-1-enyl]-5-[(S)-1-(4-methoxybenzyloxy)but-3-enyl]-2,2-dimethyl-1,3-dioxolane 

Relevant academic research and scientific papers

Asymmetric total syntheses of cochliomycin A and zeaenol

The first asymmetric total syntheses of two resorcylic acid lactones (RALs) - cochliomycin A and zeaenol - have been achieved in a divergent way. The main highlight of our strategy involves successful application of stereoselecive Keck allylation and Julia-Kocienski olefination to access an advanced intermediate, by starting from L-tartaric acid as a chiral pool compound. This intermediate is coupled with a trisubstituted benzoic acid to afford a common RCM precursor for both target molecules. Ring-closing metathesis at a late stage, followed by functional group manipulation, yielded the target molecules in an efficient way. Two resorcylic acid lactones (RALs) - cochliomycin A and zeaenol - have been synthesized for the first time by an enantiodivergent route from the common chiral pool compound L-tartaric acid. Copyright

Carbohydrate-Based Studies Toward the Synthesis of Hamigeromycin E: A Stereoselective Total Synthesis of an Isomer of Zeaenol

A stereoselective synthesis of 14-membered macrolide hamigeromycin E (6) has been studied by employing ortho-lithiated formylation, Barbier allylation, Julia–Kocienski olefination, Mitsunobu esterification, and ring-closing metathesis (RCM) reactions. The