1403659-64-2

Upstream product

• 16285-33-9 2,3-dihydro-2-phenyl-3-(phenylmethyl)-4(1H)-quinazolinone 
• 100-46-9 benzylamine 
• 401605-31-0 N-benzyl-2-iodo-5-bromobenzene-carboxamide 
• 98815-39-5 (Z)-3-amino-1,3-diphenylprop-2-en-1-one 
• 21740-00-1 5-bromo-2-iodo-benzoic acid 
• 293738-03-1 5-bromo-2-iodobenzoyl chloride 
• 120-46-7 1,3-diphenylpropanedione 
• 5471-20-5 2-amino-N-benzylbenzamide 

Relevant academic research and scientific papers

Syntheses of quinazolinones from 2-iodobenzamides and enaminones via copper-catalyzed domino reactions

N-Substituted 2-iodobenzamides and enaminones undergo cascade transformations to achieve quinazolinones via a copper-catalyzed Ullmann-type coupling, a Michael addition and a retro-Mannich reaction. A unique stereochemical feature of this domino process was that Z-enaminones reacted without external ligands, whereas E-enaminones required the assistance of ligands. This journal is

Direct halogenation reactions in 2,3-dihydro-4(1H)-quinazolinones

Reaction of 2,3-dihydro-4(1H)-quinazolinones with NBS, Br 2/Et3N and NCS yields 6,8-Br/Cl-2,3-dihydro-4(1H)- quinazolinones with moderate to good yield. The method does not require a catalyst and offers extremely short reaction time.