1403665-90-6

Usage

Structure

Benzothiazole derivative with an amino group (-NH2) and a methoxy group (-OCH3) at specific positions on the benzene ring.

Utility

Organic Synthesis: Used as a building block for synthesizing various biologically active molecules.
Pharmaceutical Research: Employed in the development of pharmaceutical compounds.

Fluorescent Properties

Exhibits fluorescence, making it suitable for the creation of fluorescent probes and dyes for biological imaging applications.

Applications

Chemistry: Valuable tool in organic synthesis.
Pharmacology: Used in pharmaceutical research.
Materials Science: Potential applications in materials research and development.

Upstream product

• 1147550-11-5 ammonium thiocyanate 
• 136-90-3 4-methoxy-3-methylaniline 
• 333-20-0 potassium thioacyanate 

Downstream Products

• 1403665-94-0 7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-ol 
• 1403665-95-1 7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl trifluoromethanesulfonate 
• 1403665-96-2 7-(4-chlorophenyl)-5-methyl-6-vinylbenzo[d]thiazole 
• 1403665-97-3 (S)-1-(7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)ethane-1,2-diol 
• 1403665-98-4 (S)-2-(7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-hydroxyethyl pivalate 
• 1403665-99-5 (S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)ethyl pivalate 
• 1403666-00-1 (S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)ethanol 
• 1403665-81-5 (S)-tert-butoxy-2-(7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)acetic acid 
• 1403666-04-5 7-(4-chlorophenyl)-6-methoxy-5-methylbenzo[d]thiazol-2-amine 

Relevant academic research and scientific papers

Molecular modelling design, synthesis and cytotoxic evaluation of certain substituted 2-(3,4,5-triacetoxybenzoylamino)benzo[d]thiazole and 2-(galloylamino)benzo[d]thiazole derivatives having potential topoisomerase-I inhibitory activity

New 2-(3,4,5-triacetoxybenzoylamino)benzothiazoles (4a~5f) and 2-(galloylamino)benzothiazoles (6a~7f), were designed as topoisomerase-I inhibitors. Compare/fit studies between these molecules and the generated topoisomerase-I inhibitors hypothesis reveale

An efficient one-pot synthesis of 2-aminobenzothiazoles from substituted anilines using benzyltrimethylammonium dichloroiodate and ammonium thiocyanate in DMSO:H2O

Treatment of a variety of substituted anilines with benzyltrimethylammonium dichloroiodate (1.2 equiv) and ammonium thiocyanate (1.0 equiv) in DMSO:H2O (9:1) at 70 °C gave the corresponding 2-aminobenzothiazoles in excellent isolated yields (75–97%; ave. yield for all substrates = 90%). The reaction worked well for 2(4)-mono-, 2,4-di-, or 3,4,5-tri-substituted anilines, and a wide range of both electron donating groups (MeO, HO, CF3O, Me) and electron withdrawing groups (NO2, CN, CO2Et, CO2H, Cl, F) were well tolerated. This method provides a useful alternative to other methods that are either less efficient (requiring 3–7 fold equivalents of reagents) or utilize highly toxic and corrosive liquid Br2 as the oxidizing agent.

BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS

Disclosed are compounds of Formula (I) to (VIII): (I) (II) (III) (IV) (V) (VI) (VII) (VIII); or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein R3 is a bicyclic heteroaryl group substituted with zero to 3 R3a; and R1, R2, R3a, R4, and n are defined herein. Also disclosed are methods of using such compounds as PAR4 inhibitors, and pharmaceutical compositions comprising such compounds. These compounds are useful in inhibiting or preventing platelet aggregation, and are useful for the treatment of a thromboembolic disorder or the primary prophylaxis of a thromboembolic disorder.

BENZOTHIAZOLE COMPOUNDS AND THEIR PHARMACEUTICAL USE

The invention provides compounds of formula I: or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for prep