1403678-01-2

Basic information

• Product Name: C₅₉H₇₀N₁₀O₁₃
• CAS NO: 1403678-01-2
• Molecular Weight: 1127.26
• Mol File: 1403678-01-2.mol

Chemical Properties

• CAS DataBase Reference: C₅₉H₇₀N₁₀O₁₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₅₉H₇₀N₁₀O₁₃(1403678-01-2)
• EPA Substance Registry System: C₅₉H₇₀N₁₀O₁₃(1403678-01-2)

Safety Data

• Hazardous Substances Data: 1403678-01-2(Hazardous Substances Data)

Upstream product

• 125847-08-7 1-(4-methylphenyl)-1,2,2-triphenylethanol 
• 1403677-99-5 (2-(4-(azidomethyl)phenyl)ethene-1,1,2-triyl)tribenzene 
• 1403678-00-1 C₃₂H₄₉N₇O₁₃ 
• 101-81-5 Diphenylmethane 
• 134-84-9 4-Methylbenzophenone 

Relevant articles and documents

Real-time monitoring of cell apoptosis and drug screening using fluorescent light-up probe with aggregation-induced emission characteristics

Real-time monitoring of cell apoptosis could provide valuable insights into early detection of therapy efficiency and evaluation of disease progression. In this work, we designed and synthesized a new live-cell-permeable, fluorescent light-up probe for real-time cell apoptosis imaging. The probe is comprised of a hydrophilic caspase-specific Asp-Glu-Val-Asp (DEVD) peptide and a hydrophobic tetraphenylethene (TPE) unit, a typical fluorogen with aggregation-induced emission characteristics. In aqueous solution, the probe is almost nonfluorescent but displays significant fluorescence enhancement in response to caspase-3/-7, which are activated in the apoptotic process and able to cleave the DEVD moieties. This fluorescence "turn-on" response is ascribed to aggregation of cleaved hydrophobic TPE residues, which restricts the intramolecular rotations of TPE phenyl rings and populates the radiative decay channels. The light-up nature of the probe allows real-time monitoring of caspase-3/-7 activities both in solutions and in living cells with a high signal-to-noise ratio. The probe provides a new opportunity to screen enzyme inhibitors and evaluate the apoptosis-associated drug efficacy.