1403679-96-8Relevant articles and documents
Pyrrole-3-carboxamides as potent and selective JAK2 inhibitors
Brasca, Maria Gabriella,Nesi, Marcella,Avanzi, Nilla,Ballinari, Dario,Bandiera, Tiziano,Bertrand, Jay,Bindi, Simona,Canevari, Giulia,Carenzi, Davide,Casero, Daniele,Ceriani, Lucio,Ciomei, Marina,Cirla, Alessandra,Colombo, Maristella,Cribioli, Sabrina,Cristiani, Cinzia,Della Vedova, Franco,Fachin, Gabriele,Fasolini, Marina,Felder, Eduard R.,Galvani, Arturo,Isacchi, Antonella,Mirizzi, Danilo,Motto, Ilaria,Panzeri, Achille,Pesenti, Enrico,Vianello, Paola,Gnocchi, Paola,Donati, Daniele
, p. 4998 - 5012 (2014/10/16)
We report herein the discovery, structure guided design, synthesis and biological evaluation of a novel class of JAK2 inhibitors. Optimization of the series led to the identification of the potent and orally bioavailable JAK2 inhibitor 28 (NMS-P953). Comp
SUBSTITUTED PYRIMIDINYL-PYRROLES ACTIVE AS KINASE INHIBITORS
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Page/Page column 29, (2012/11/07)
The present invention relates to substituted pyrimidinyl-pyrrole compounds of formula (I) which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular Janus kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such compounds or the pharmaceutical compositions containing them.