1403679-53-7Relevant articles and documents
Pyrrole-3-carboxamides as potent and selective JAK2 inhibitors
Brasca, Maria Gabriella,Nesi, Marcella,Avanzi, Nilla,Ballinari, Dario,Bandiera, Tiziano,Bertrand, Jay,Bindi, Simona,Canevari, Giulia,Carenzi, Davide,Casero, Daniele,Ceriani, Lucio,Ciomei, Marina,Cirla, Alessandra,Colombo, Maristella,Cribioli, Sabrina,Cristiani, Cinzia,Della Vedova, Franco,Fachin, Gabriele,Fasolini, Marina,Felder, Eduard R.,Galvani, Arturo,Isacchi, Antonella,Mirizzi, Danilo,Motto, Ilaria,Panzeri, Achille,Pesenti, Enrico,Vianello, Paola,Gnocchi, Paola,Donati, Daniele
, p. 4998 - 5012 (2014/10/16)
We report herein the discovery, structure guided design, synthesis and biological evaluation of a novel class of JAK2 inhibitors. Optimization of the series led to the identification of the potent and orally bioavailable JAK2 inhibitor 28 (NMS-P953). Comp