1403680-12-5

Basic information

• Product Name: 5-(2-aminopyrimidin-4-yl)-2-(5-chloro-2-methyl-phenyl)-1H-pyrrole-3-carboxylic acid
• Synonyms: 5-(2-aminopyrimidin-4-yl)-2-(5-chloro-2-methyl-phenyl)-1H-pyrrole-3-carboxylic acid
• CAS NO: 1403680-12-5
• Molecular Weight: 328.758
• Mol File: 1403680-12-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-(2-aminopyrimidin-4-yl)-2-(5-chloro-2-methyl-phenyl)-1H-pyrrole-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-aminopyrimidin-4-yl)-2-(5-chloro-2-methyl-phenyl)-1H-pyrrole-3-carboxylic acid(1403680-12-5)
• EPA Substance Registry System: 5-(2-aminopyrimidin-4-yl)-2-(5-chloro-2-methyl-phenyl)-1H-pyrrole-3-carboxylic acid(1403680-12-5)

Safety Data

• Hazardous Substances Data: 1403680-12-5(Hazardous Substances Data)

Upstream product

• 148839-33-2 (5-chloro-2-methylphenyl)boronic acid 
• 951784-50-2 ethyl 4-(2-aminopyrimidin-4-yl)-2-cyano-4-oxobutanoate 
• 106157-91-9 1-(2-amino-pyrimidin-4-yl)-2-bromo-ethanone hydrobromide 

Downstream Products

• 1403679-51-5 5-(2-aminopyrimidin-4-yl)-2-(5-chloro-2-methylphenyl)-N-methyl-1H-pyrrole-3-carboxamide 
• 1403679-61-7 5-(2-aminopyrimidin-4-yl)-2-(5-chloro-2-methylphenyl)-N,N-dimethyl-1H-pyrrole-3-carboxamide 
• 1403679-52-6 5-(2-aminopyrimidin-4-yl)-2-(5-chloro-2-methylphenyl)-N-ethyl-1H-pyrrole-3-carboxamide 
• 1403679-53-7 5-(2-aminopyrimidin-4-yl)-2-(5-chloro-2-methylphenyl)-N-(2-hydroxyethyl)-1H-pyrrole-3-carboxamide 
• 1403679-60-6 5-(2-aminopyrimidin-4-yl)-2-(5-chloro-2-methylphenyl)-N-(2-fluoroethyl)-1H-pyrrole-3-carboxamide 
• 1403679-59-3 5-(2-aminopyrimidin-4-yl)-2-(5-chloro-2-methylphenyl)-N-(2-methoxyethyl)-1H-pyrrole-3-carboxamide 
• 1403679-65-1 5-(2-aminopyrimidin-4-yl)-2-(5-chloro-2-methylphenyl)-N-(2-methylpropyl)-1H-pyrrole-3-carboxamide 
• 1403679-64-0 5-(2-aminopyrimidin-4-yl)-N-benzyl-2-(5-chloro-2-methylphenyl)-1H-pyrrole-3-carboxamide 
• 1403679-56-0 5-(2-aminopyrimidin-4-yl)-2-(5-chloro-2-methylphenyl)-N-phenyl-1H-pyrrole-3-carboxamide 
• 1403679-55-9 5-(2-aminopyrimidin-4-yl)-2-(5-chloro-2-methylphenyl)-N-(1-methylpiperidin-4-yl)-1H-pyrrole-3-carboxamide 
• 1403679-63-9 5-(2-aminopyrimidin-4-yl)-2-(5-chloro-2-methylphenyl)-N-[2-(methylamino)ethyl]-1H-pyrrole-3-carboxamide 

Relevant articles and documents

Pyrrole-3-carboxamides as potent and selective JAK2 inhibitors

We report herein the discovery, structure guided design, synthesis and biological evaluation of a novel class of JAK2 inhibitors. Optimization of the series led to the identification of the potent and orally bioavailable JAK2 inhibitor 28 (NMS-P953). Comp

SUBSTITUTED PYRIMIDINYL-PYRROLES ACTIVE AS KINASE INHIBITORS

The present invention relates to substituted pyrimidinyl-pyrrole compounds of formula (I) which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular Janus kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such compounds or the pharmaceutical compositions containing them.