1403950-74-2Relevant academic research and scientific papers
Synthesis and SAR studies of fused oxadiazines as γ-secretase modulators for treatment of Alzheimer's disease
Huang, Xianhai,Zhou, Wei,Liu, Xiaoxiang,Li, Hongmei,Sun, George,Mandal, Mihirbaran,Vicarel, Monica,Zhu, Xiaohong,Bennett, Chad,McCraken, Troy,Pissarnitski, Dmitri,Zhao, Zhiqiang,Cole, David,Gallo, Gioconda,Zhu, Zhaoning,Palani, Anandan,Aslanian, Robert,Clader, John,Czarniecki, Michael,Greenlee, William,Burnett, Duane,Cohen-Williams, Mary,Hyde, Lynn,Song, Lixin,Zhang, Lili,Chu, Inhou,Buevich, Alexei
, p. 931 - 935 (2013/01/15)
Fused oxadiazines (3) were discovered as selective and orally bioavailable γ-secretase modulators (GSMs) based on the structural framework of oxadiazoline GSMs. Although structurally related, initial modifications showed that structure-activity relationsh
