1403983-41-4Relevant academic research and scientific papers
Design and synthesis of some thieno[2,3-c]pyridazine derivatives of expected anticancer activity
El-Ansary, Afaf K.,Kamal, Aliaa M.,Al-Ghorafi, Mokhtar Abdhafiz
, p. 2589 - 2601 (2013/07/26)
Design and synthesis of some new thienopyridazine derivatives as anticancer agents were the goal of this work. Accordingly, a series of novel compounds were synthesized via reacting thienopyridazine carboxylic acid hydrazide with different organic reagents. Twelve novel compounds were selected by National Cancer Institute for a full anticancer screening assay where seven of the investigated compounds showed non-selective broad spectrum and promising activity almost against all cancer cell lines. One of the most active compounds was chosen to be evaluated against 60-cell line panel at five concentration levels and revealed a remarkable growth inhibition activity.
