521941-63-9

Upstream product

• 112450-33-6 ethyl 2,3-dihydro-5,6-diphenyl-3-thioxo-2,3-dihydro-4-pyridazinecarboxylate 
• 105-39-5 chloroacetic acid ethyl ester 
• 5344-88-7 benzil monohydrazone 
• 54108-27-9 ethyl 3-chloro-5,6-diphenylpyridazine-4-carboxylate 

Downstream Products

• 1403983-52-7 5-hydroxy-3,4-diphenylthieno[2,3-c]pyridazine-6-carboxylic acid (ZE) (2-nitrobenzylidene)hydrazide 
• 1403983-40-3 N-[5-hydroxy-3,4-diphenylthieno[2,3-c]pyridazine-6-carboxylic acid amido]isoindole-1,3-dione 
• 1403983-41-4 5-methyl-2-(5-hydroxy-3,4-diphenylthieno[2,3-c]pyridazine-6-carbonyl)-2,4-dihydropyrazol-3-one 
• 1403983-42-5 6-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)-5-hydroxy-3,4-diphenylthieno[2,3-c]pyridazine 
• 1403983-45-8 C₂₁H₁₇N₅O₂S₂ 
• 1403983-50-5 5-hydroxy-3,4-diphenyl-6-(5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl)thieno[2,3-c]pyridazine 
• 1403983-43-6 6-(5-methylsulfanyl[1,3,4]oxadiazol-2-yl)-3,4-diphenylthieno[2,3-c]pyridazin-5-ol 
• 1403983-44-7 5-methoxy-6-(5-methylsulfanyl[1,3,4]oxadiazol-2-yl)-3,4-diphenylthieno[2,3-c]pyridazine 
• 1403983-54-9 6-(5-benzylsulfanyl[1,3,4]oxadiazol-2-yl)-3,4-diphenylthieno[2,3-c]pyridazin-5-ol 
• 1403983-55-0 5-benzyloxy-6-(5-benzylsulfanyl[1,3,4]oxadiazol-2-yl)-3,4-diphenylthieno[2,3-c]pyridazine 
• 1403983-46-9 5-hydroxy-3,4-diphenylthieno[2,3-c]pyridazine-6-carboxylic acid (ZE) (3-methyl-4-oxothiazolidin-2-ylidene)hydrazide 
• 1403983-47-0 5-hydroxy-6-(5-methylamino-1,3,4-thiadiazol-2-yl)-3,4-diphenylthieno[2,3-c]pyridazine 
• 1403983-48-1 C₂₁H₁₅N₅OS₂ 

Relevant academic research and scientific papers

Design and synthesis of some thieno[2,3-c]pyridazine derivatives of expected anticancer activity

Design and synthesis of some new thienopyridazine derivatives as anticancer agents were the goal of this work. Accordingly, a series of novel compounds were synthesized via reacting thienopyridazine carboxylic acid hydrazide with different organic reagents. Twelve novel compounds were selected by National Cancer Institute for a full anticancer screening assay where seven of the investigated compounds showed non-selective broad spectrum and promising activity almost against all cancer cell lines. One of the most active compounds was chosen to be evaluated against 60-cell line panel at five concentration levels and revealed a remarkable growth inhibition activity.