54108-27-9

Usage

InChI:InChI=1/C19H15ClN2O2/c1-2-24-19(23)16-15(13-9-5-3-6-10-13)17(21-22-18(16)20)14-11-7-4-8-12-14/h3-12H,2H2,1H3

Upstream product

• 5344-88-7 benzil monohydrazone 
• 105-53-3 diethyl malonate 

Downstream Products

• 147235-62-9 ethyl 5,6-diphenyl-3-(triphenylphosphoranylideneamino)pyridazin-4-carboxylate 
• 192826-76-9 3-Chloro-5,6-diphenyl-pyridazine-4-carboxylic acid 
• 646996-79-4 ethyl 6,7-diphenyltetrazolo[1,5-b]pyridazine-8-carboxylate 
• 82231-91-2 3-oxo-5,6-diphenyl-2,3-dihydro-pyridazine-4-carboxylic acid 
• 192826-77-0 1-Chloro-4-phenyl-indeno[1,2-d]pyridazin-9-one 
• 147235-67-4 5,6-diphenyl-2-(4-nitrophenyl)pyridazino<3,4-d><3,1>oxazin-4-one 
• 1403983-38-9 5-hydroxy-3,4-diphenylthieno[2,3-c]pyridazine-6-carboxylic acid (ZE) (4-fluorobenzylidene)hydrazide 
• 1403983-52-7 5-hydroxy-3,4-diphenylthieno[2,3-c]pyridazine-6-carboxylic acid (ZE) (2-nitrobenzylidene)hydrazide 
• 1403983-40-3 N-[5-hydroxy-3,4-diphenylthieno[2,3-c]pyridazine-6-carboxylic acid amido]isoindole-1,3-dione 
• 1403983-41-4 5-methyl-2-(5-hydroxy-3,4-diphenylthieno[2,3-c]pyridazine-6-carbonyl)-2,4-dihydropyrazol-3-one 
• 1403983-42-5 6-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)-5-hydroxy-3,4-diphenylthieno[2,3-c]pyridazine 
• 1403983-43-6 6-(5-methylsulfanyl[1,3,4]oxadiazol-2-yl)-3,4-diphenylthieno[2,3-c]pyridazin-5-ol 
• 1403983-44-7 5-methoxy-6-(5-methylsulfanyl[1,3,4]oxadiazol-2-yl)-3,4-diphenylthieno[2,3-c]pyridazine 
• 1403983-54-9 6-(5-benzylsulfanyl[1,3,4]oxadiazol-2-yl)-3,4-diphenylthieno[2,3-c]pyridazin-5-ol 

Relevant academic research and scientific papers

Design and synthesis of some thieno[2,3-c]pyridazine derivatives of expected anticancer activity

Design and synthesis of some new thienopyridazine derivatives as anticancer agents were the goal of this work. Accordingly, a series of novel compounds were synthesized via reacting thienopyridazine carboxylic acid hydrazide with different organic reagents. Twelve novel compounds were selected by National Cancer Institute for a full anticancer screening assay where seven of the investigated compounds showed non-selective broad spectrum and promising activity almost against all cancer cell lines. One of the most active compounds was chosen to be evaluated against 60-cell line panel at five concentration levels and revealed a remarkable growth inhibition activity.