140412-95-9 Usage
Properties
1. Chemical name: 2-amino-7,8-dimethyl-10-propyldibenzo[b,f][1,4]oxazepin-11(10H)-one
2. Common name: clozapine
3. Use: psychoactive medication used to treat schizophrenia
4. Class: tricyclic dibenzodiazepine
5. Mechanism of action: antagonism of dopamine receptors in the brain
6. Unique property: effective in treatment-resistant cases of schizophrenia
7. Side effects: potentially serious side effects, such as agranulocytosis
8. Monitoring requirement: regular monitoring of blood cell counts while taking the medication
Specific content
Clozapine is known for its effectiveness in treating schizophrenia, particularly in cases where other medications have failed.
It belongs to the class of tricyclic dibenzodiazepines and works by antagonizing dopamine receptors in the brain.
One of the unique properties of clozapine is its ability to treat treatment-resistant cases of schizophrenia.
However, it is associated with potentially serious side effects, such as agranulocytosis, which requires regular monitoring of blood cell counts.
Despite its drawbacks, clozapine remains an important tool in the treatment of schizophrenia, especially in cases that have not responded to other medications.
Check Digit Verification of cas no
The CAS Registry Mumber 140412-95-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,0,4,1 and 2 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 140412-95:
(8*1)+(7*4)+(6*0)+(5*4)+(4*1)+(3*2)+(2*9)+(1*5)=89
89 % 10 = 9
So 140412-95-9 is a valid CAS Registry Number.
140412-95-9Relevant academic research and scientific papers
Novel Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase. 2. Tricyclic Pyridobenzoxazepinones and Dibenzoxazepinones
Klunder, Janice M.,Hargrave, Karl D.,West, MaryAnn,Cullen, Ernest,Pal, Kollol,et al.
, p. 1887 - 1897 (2007/10/02)
Dibenzoxazepin-11(10H)-ones (III), pyridobenzoxazepin-6(5H)-ones (IV), and pyridobenzoxazepin-5(6H)-ones (V) were found to inhibit human immunodeficiency virus type 1 reverse transcriptase with IC50 values as 19 nM.A-ring substitution has a profound effect on activity, with appropriate substituents at the positions ortho and para to the lactam nitrogen providing dramatically enhanced potency.Substitution in the C-ring is generally neutral or detrimental to activity.Although a C-ring amino substituent at the position meta to the lactam carbonyl is generally beneficial to activity, it has essentially no effect when the A-ring is optimally substituted.Like the dipyridodiazepinone nevirapine, compounds III-V are specific for HIV-1 RT, exhibiting no inhibitory activity against HIV-2 RT or other virial reverse transcriptase enzymes.
