335209-83-1

Basic information

• Product Name: 2-Chloro-N-(2-hydroxy-4,5-dimethyl-phenyl)-5-nitro-benzamide
• Synonyms: 2-Chloro-N-(2-hydroxy-4,5-dimethyl-phenyl)-5-nitro-benzamide
• CAS NO: 335209-83-1
• Molecular Weight: 320.732
• Mol File: 335209-83-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Chloro-N-(2-hydroxy-4,5-dimethyl-phenyl)-5-nitro-benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-N-(2-hydroxy-4,5-dimethyl-phenyl)-5-nitro-benzamide(335209-83-1)
• EPA Substance Registry System: 2-Chloro-N-(2-hydroxy-4,5-dimethyl-phenyl)-5-nitro-benzamide(335209-83-1)

Safety Data

• Hazardous Substances Data: 335209-83-1(Hazardous Substances Data)

Upstream product

• 2516-96-3 2-chloro-5-nitrobenzoic acid 
• 6623-41-2 2-amino-4,5-dimethylphenol 
• 25784-91-2 2-chloro-5-nitrobenzoylchloride 

Downstream Products

• 140412-95-9 2-Amino-7,8-dimethyl-10-propyl-10H-dibenzo[b,f][1,4]oxazepin-11-one 

Relevant articles and documents

Novel Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase. 2. Tricyclic Pyridobenzoxazepinones and Dibenzoxazepinones

Dibenzoxazepin-11(10H)-ones (III), pyridobenzoxazepin-6(5H)-ones (IV), and pyridobenzoxazepin-5(6H)-ones (V) were found to inhibit human immunodeficiency virus type 1 reverse transcriptase with IC50 values as 19 nM.A-ring substitution has a profound effect on activity, with appropriate substituents at the positions ortho and para to the lactam nitrogen providing dramatically enhanced potency.Substitution in the C-ring is generally neutral or detrimental to activity.Although a C-ring amino substituent at the position meta to the lactam carbonyl is generally beneficial to activity, it has essentially no effect when the A-ring is optimally substituted.Like the dipyridodiazepinone nevirapine, compounds III-V are specific for HIV-1 RT, exhibiting no inhibitory activity against HIV-2 RT or other virial reverse transcriptase enzymes.