14042-01-4

Basic information

• Product Name: PEROXYNITRITE
• Synonyms: SODIUM PEROXYNITRITE;PEROXYNITRITE TETRAMETHYLAMMONIUM;PEROXYNITRITE TETRAMETHYLAMMONIUM SALT;PEROXYNITROUS ACID, SODIUM SALT;PEROXYNITRITE;[N(CH3)4][ONOO];WLBPQQFLRJVMBK-UHFFFAOYSA-M
• CAS NO: 14042-01-4
• Molecular Formula: HNO3
• Molecular Weight: 63.01
• Mol File: 14042-01-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: PEROXYNITRITE(CAS DataBase Reference)
• NIST Chemistry Reference: PEROXYNITRITE(14042-01-4)
• EPA Substance Registry System: PEROXYNITRITE(14042-01-4)

Safety Data

• Hazardous Substances Data: 14042-01-4(Hazardous Substances Data)

Usage

General Description

Peroxynitrite is a highly reactive and toxic molecule that is formed in the body through the reaction of nitric oxide and superoxide radical. It is considered to be a major contributor to oxidative stress and tissue damage in various disease states, including cardiovascular diseases, neurodegenerative disorders, and inflammatory conditions. Peroxynitrite is known for its ability to cause lipid peroxidation, protein nitration, and DNA damage, leading to cell dysfunction and death. It also plays a role in the regulation of immune responses and inflammation. The imbalance between peroxynitrite formation and scavenging mechanisms has been implicated in the pathogenesis of several diseases, making it a target for therapeutic intervention.

Upstream product

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Relevant articles and documents

Hemin-functionalized reduced graphene oxide nanosheets reveal peroxynitrite reduction and isomerization activity

Facile and efficient reduction of graphene oxide (GO) and novel applications of the reduced graphene oxide (RGO) based materials are of current interest. Herein, we report a novel and facile method for the reduction of GO by using a biocompatible reducing agent dithiothreitol (DTT). Stabilization of DTT by the formation of a six-membered ring with internal disulfide linkage upon oxidation is responsible for the reduction of GO. The reduced graphene oxide is characterized by several spectroscopic and microscopic techniques. Dispersion of RGO in DMF remained stable for several weeks suggesting that the RGO obtained by DTT-mediated reduction is hydrophobic in nature. This method can be considered for large scale production of good quality RGO. Treatment of RGO with hemin afforded a functional hemin-reduced graphene oxide (H-RGO) hybrid material that exhibited remarkable protective effects against the potentially harmful peroxynitrite (PN). A detailed inhibition study on PN-mediated oxidation and nitration reactions indicate that the interaction between hemin and RGO results in a synergistic effect, which leads to an efficient reduction of PN to nitrate. The RGO also catalyzes the isomerization of PN to nitrate as the RGO layers facilitate the rapid recombination of .NO2 with FeIV=O species. In the presence of reducing agents such as ascorbic acid, the FeIV=O species can be reduced to FeIII, thus helping to maintain the PN reductase cycle.

Relationship between the Structure and Chaperone Activity of Human αA-Crystallin after Its Modification with Diabetes-Associated Oxidative Agents and Protective Role of Antioxidant Compounds

Abstract: The study was aimed to evaluate the impact of peroxynitrite (PON, oxidative stress agent in diabetes), methylglyoxal (MGO, diabetes-associated reactive carbonyl compound), and their simultaneous application on the structural and functional features of human αA-crystallin (αA-Cry) using various spectroscopy techniques. Additionally, the surface tension and oligomer size distribution of the treated and untreated protein were tested using tensiometric analysis and dynamic light scattering, respectively. Our results indicated that the reaction of PON and MGO with human αA-Cry leads to the formation of new chromophores, alterations in the secondary to quaternary protein structure, reduction in the size of protein oligomers, and significant enhancement in the chaperone activity of αA-Cry. To reverse the effects of the tested compounds, ascorbic acid and glutathione (main components of lens antioxidant defense system) were applied. As expected, the two antioxidant compounds significantly prevented formation of high molecular weight aggregates of αA-Cry (according to SDS-PAGE). Our results suggest that the lens antioxidant defense system, in particular, glutathione, may provide a strong protection against rapid incidence and progression of diabetic cataract by preventing the destructive reactions of highly reactive DM-associated metabolites.

Compositions and methods of use of 8-nitroguanine

Novel methods for the synthesis of 8-nitroguanine are provided. Compositions comprising 8-nitroguanine, made by the novel synthetic methods are also provided herein. Methods of use of 8-nitroguanine, made by the novel synthetic methods, as a standard for detection of 8-nitroguanine in samples are also encompassed within the scope of the present invention. The present invention further concerns methods of predicting organ transplant rejection and detecting exposure to environmental stressors, such as ionizing radiation, toxic chemicals or infectious agents, by detecting 8-nitroguanine in one or more samples from a transplant recipient or an organism exposed to stress.