1404219-98-2Relevant academic research and scientific papers
Three-component heterocyclization of gem -bromofluorocyclopropanes with NOBF4: Access to 4-fluoropyrimidine N -oxides
Sedenkova, Kseniya N.,Averina, Elena B.,Grishin, Yuri K.,Kutateladze, Andrei G.,Rybakov, Victor B.,Kuznetsova, Tamara S.,Zefirov, Nikolay S.
, p. 9893 - 9899 (2012)
Novel three-component heterocyclization involving gem- bromofluorocyclopropanes, nitrosyl tetrafluoroborate, and a molecule of the solvent (nitrile) yielding previously unknown fluorinated pyrimidine N-oxides is described. A two-step synthetic approach to 4-fluoropyrimidine N-oxides from alkenes under mild conditions is developed using this reaction. Mechanistic aspects of the heterocyclization are discussed.
