Three-component heterocyclization of gem -bromofluorocyclopropanes with NOBF4: Access to 4-fluoropyrimidine N -oxides

Article abstract of DOI:10.1021/jo301880m

Novel three-component heterocyclization involving gem- bromofluorocyclopropanes, nitrosyl tetrafluoroborate, and a molecule of the solvent (nitrile) yielding previously unknown fluorinated pyrimidine N-oxides is described. A two-step synthetic approach to 4-fluoropyrimidine N-oxides from alkenes under mild conditions is developed using this reaction. Mechanistic aspects of the heterocyclization are discussed.

Full text of DOI:10.1021/jo301880m

Note
pubs.acs.org/joc
Three-Component Heterocyclization of gem-
Bromofluorocyclopropanes with NOBF4: Access to
4‑Fluoropyrimidine N‑Oxides
Kseniya N. Sedenkova,†,‡ Elena B. Averina,*,†,‡ Yuri K. Grishin,† Andrei G. Kutateladze,*,§
Victor B. Rybakov,† Tamara S. Kuznetsova,†,‡ and Nikolay S. Zefirov†,‡
†Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1-3, Moscow 119991, Russia
‡IPhaC RAS, Severnyi Proezd, 1, Chernogolovka, Moscow Region 142432, Russia
§Department of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80208, United States
S
* Supporting Information
ABSTRACT: Novel three-component heterocyclization involving gem-bromofluor-
ocyclopropanes, nitrosyl tetrafluoroborate, and a molecule of the solvent (nitrile)
yielding previously unknown fluorinated pyrimidine N-oxides is described. A two-step
synthetic approach to 4-fluoropyrimidine N-oxides from alkenes under mild conditions
is developed using this reaction. Mechanistic aspects of the heterocyclization are
discussed.
luorine-substituted organic molecules found broad appli-
closure reactions, such as the condensation of amino-containing
Fcation in the design of pharmaceuticals and agro- carbonyl derivatives20−22 and nitriles23 by the treatment with
chemicals.1−4 Because of the unique combination of electro-
hydroxylamine; the cyclization of amino oximes with
orthoesters,24,25 1,3-dicarbonyl derivatives,26,27 isothiocya-
negativity and small size of the fluorine atom, introducing a
fluorine-containing substituent is an accepted way to modify
properties, increase metabolic stability of molecules, and vary
nates28 or chloroanhydrides;29 and, less general, the reaction
of nitroaromatic compounds with isocyanoacetate.30,31 It is
noteworthy that none of ring formation methods was employed
to obtain 4-halogenopyrimidine N-oxides.
their lipophilicity/hydrophilicity and selectivity of protein−
ligand interactions without perturbing their general shape.5−7
Thus, the search for new approaches to install fluorine atoms
into organic molecules, especially with the goal of accessing
new classes of fluorine-substituted heterocycles, is well justified.
Reactions between gem-dihalogenocyclopropanes and various
sources of the nitrosonium cation are known to be a
straightforward and effective way to obtain 5-halogeno-
substituted isoxazoles.8−11 We note that the prior nitrosylation
studies were limited to studying gem-dichloro- and dibromo-
cyclopropanes in the reaction, and no attempts were made to
utilize fluorine-containing cyclopropanes as a starting material.
At the same time, 1-bromo-1-fluorocyclopropanes are readily
available via cycloadditions of bromofluorocarbene to CC
double bonds under relatively mild conditions12−14 and can be
subsequently used for heterocyclizations under the conditions
promoting the opening of the three-membered ring. We
investigated a series of 1-bromo-1-fluorocyclopropanes in the
reaction with NOBF4 seeking to obtain 5-fluoroisoxazoles.
Instead, our unexpected finding was that the reaction produces
previously unknown type of heterocycles, namely 4-fluoropyr-
imidine N-oxides.
We started our studies by carrying out the reaction of 7-
bromo-7-fluorobicyclo[4.1.0]heptane (1a) with NOBF4 in
acetonitrile. At room temperature no reaction was observed,
despite the fact that the analogous gem-dichlorobicycloheptane
is known to give 5-chloroisoxazole under the same conditions.9
When the reaction mixture was refluxed for 5 h, a sole product,
4-fluoro-2-methyl-5,6,7,8-tetrahydroquinazoline 1-oxide (3a),
was obtained in 47% yield (Scheme 1). The structure of 3a
Scheme 1. Reaction of 1a with NOBF4
was proved by X-ray analysis of its complexes with CuCl2 4 and
picric acid 5 (see the Supporting Information). The ability of
pyrimidine N-oxides to complex will be a subject of a separate
investigation.
Clearly, compound 3a is a result of a three-component
heterocyclization involving bromofluorocyclopropane 1a, nitro-
syl tetrafluoroborate, and a molecule of solvent. In order to
It is worth noting that the major method of synthesis of
pyrimidine N-oxides, based on oxidation of corresponding
pyrimidines, is complicated by side reactions.15,16 Other
existing approaches to pyrimidine N-oxides15,17,18 include the
reactions of ring transformations, preferentially of 1,2,4-
oxadiazoles or pyrimidinium compounds,15,17−19 and the ring-
Received: August 31, 2012
© XXXX American Chemical Society
A
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Note
prove this assumption, we carried out this reaction in other
solvents containing cyano group and did obtain the series of 2-
substituted tetrahydroquinazoline 1-oxides 3b−d (Scheme 2).
The preferential or exclusive formation of 6-alkyl(aryl)-
substituted regioisomers of pyrimidine N-oxides were con-
firmed by their NMR spectra. Because of the presence of
fluorine atom in the molecule, we can unambiguously assign
carbon atoms in the heterocycle. The values of the JCF coupling
constants successively decrease from C(4) to C(6) (see the
Experimental Section), which is in keeping with the literature
data for 4-fluorine-substituted pyridine.32 For the assignment of
carbon atoms in the pyrimidine N-oxide cycle we carried out
DFT computations of 13C chemical shifts for the series of
pyrimidine oxides, where the structures were optimized at the
B3LYP/6-311+G(d,p) level of theory and the chemical shifts
were calculated with an uncontracted basis set of Bally and
Rablen,33 using the Gaussian 09 package. Table 1 summarizes
the experimental and calculated 13C chemical shift data for
pyrimidine N-oxides 7a−g.
The calculated chemical shifts for four heteroaromatic carbon
atoms and the methyl group in 6-alkyl(aryl)-substituted
heterocycles (Table 1) were linearly scaled as follows: δ =
197.960−1.037 δDFT. The calculated values are in excellent
agreement with the experimental spectra of regioisomers 7a,d−
g, the correlation coefficients of linear regressions R being over
0.998; average rmsd values for all compounds are within the
1.7−2.9 ppm range. In contrast, the rmsd values for other
possible isomers of pyrimidine N-oxides are much worse,
ranging from 5.7 to 11.4 ppm. Thus, the results of the DFT
chemical shifts calculations provide additional arguments in
favor of the 6-substituted isomers.
Both ionic and radical pathways are proposed in the literature
for the reaction of cyclopropanes with nitrosonium cation
which may act as an electrophilic nitrosylation reagent and also
as a strong one-electron oxidant.8−11,34,35 Two mechanistic
rationales could be therefore postulated. The first step of the
ionic pathway involves the electrophilic attack of NO+ and the
opening of the three-membered ring (path A, Scheme 4)
resulting in the formation of the intermediate II. The
alternative pathway is the single electron transfer from
dihalogenocyclopropane I to NO+ cation, leading to cation-
radical species III and NO molecule. Subsequent recombina-
tion of III and NO, results in the formation of carbocation II
(path B, Scheme 4), identical to the one shown in the course of
path A. According to the calculations DFT B3LYP/6-
311+G(d,p) for the model structure I (R1 = H, R2 = CH3)
the ring-opening of the cyclopropane with the NO+ cation
(path A) is an exergonic process (−35 kcal/mol), whereas the
one-electron transfer leading to the intermediate III is slightly
endergonic (+1.5 kcal/mol for E- and +2.5 kcal/mol for Z-
isomer I), which makes electrophilic path A for generation of
the cation II more plausible. The alternative regiochemistry of
Scheme 2. Heterocyclization of 1a in Various Solvents
Propionitrile and trimethylacetonitrile gave heterocycles 3b and
3c as the sole products, but in the case of benzonitrile side
products of substitution in the phenyl ring of the solvent
formed, complicating the isolation of tetrahydroquinazoline
oxide 3d.
Next, we probed the scope and limitation of the new three-
component heterocyclization in a series of substituted 1-bromo-
1-fluorocyclopropanes 6a−g, which were obtained via the [1 +
2]-cycloaddition of bromofluorocarbene to alkenes under the
phase-transfer conditions.12 Cyclopropanes 6a−g were inves-
tigated in the reaction with NOBF4 in acetonitrile: the results
are summarized in Scheme 3.
Alkyl-substituted 1-bromo-1-fluorocyclopropanes 6a,b in the
reaction with NOBF4 gave the pyrimidine N-oxides with
preferential formation of 6-alkyl-substituted regioisomers 7a,b.
According to the NMR of reaction mixtures of 6a and 6b with
the nitrosylation reagent alternative 5-alkyl-substituted re-
gioisomers 8a and 8b were formed in 20 and 30% yield,
respectively. After column chromatography, butyl-substituted
pyrimidine N-oxide was obtained as a mixture of two
regioisomers 7a/8a in 3:1 ratio. 6-Hexyl-substituted heterocycle
7b was isolated from the reaction mixture as a sole isomer.
No heterocyclization occurred under nitrosylation of benzyl-
substituted dihalogenocyclopropane 6c. Neither extending the
time of the reaction to 24 h, nor excess of NOBF4, nor
microwave activation produced the expected heterocycle. The
only products observed in the reaction mixture besides the
starting cyclopropane 6c were the products of nitration of the
phenyl ring. Such result is in agreement with the literature data
for benzyl-substituted dichlorocyclopropanes.10
On the contrary, aryl-substituted compounds 6d−g reacted
with NOBF4 rapidly at room temperature giving the
corresponding 6-aryl-substituted pyrimidine N-oxides 7d−g.
Markedly, these reactions proceeded with high regioselectivity,
and no traces of 5-aryl-substituted isomers were observed in the
reaction mixture.
Scheme 3. Synthesis of 1-Bromo-1-fluorocyclopropanes 6a−g and Their Reaction with NOBF4
B
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Note
Table 1. Experimental and Calculated by DFT Method 13C Chemical Shifts (ppm) for Pyrimidine N-Oxides
CH3
C(2)
C(4)
C(5)
C(6)
a
N
expt
calcd
expt
calcd
expt
calcd
expt
calcd
expt
calcd
rmsd
7a
7d
7e
7f
20.0
20.4
20.4
20.3
20.3
21.03
21.03
21.41
21.34
21.17
159.1
160.5
161.0
161.0
160.5
161.12
161.12
163.47
163.87
162.04
156.8
156.7
157.3
156.6
156.6
153.84
153.84
154.68
154.59
153.07
104.2
105.3
105.6
105.5
107.3
103.58
103.58
103.17
103.27
105.04
163.8
157.9
156.8
155.2
154.7
163.31
163.31
156.60
155.96
158.38
1.7
2.9
2.0
1.9
2.6
7g
a
Root mean square deviation (rmsd, ppm).
Scheme 4. Mechanism of Formation of the Pyrimidine N-Oxides
Scheme 5. Reaction of 1b−d with NOBF4
Table 2. Natural Atomic Charges Calculated for the Halogens and the Cationic Carbon in the Model System O
NC(CH3)CH2C+Hal1Hal2 IXa−f
the initial attack of the NO+ cation could also lead to the cation
C. However, the calculations predict the cation C (R1 = H, R2 =
CH3) to be 7 kcal/mol less stable than the cation II (R1 = H, R2
= CH3), stabilized by two halogen atoms. These calculation
results correspond to the structure of the experimentally
observed products 3a−d and 7a,b,d−g.
which implies that bromine is acting as a leaving group in
intermediate VIII.
In contrast, in the case of gem-bromofluorocyclopropane 1a,
6a,b,d−g, intermediate II is trapped by solvent, resulting in the
formation of nitrilium species IV (step 2, Scheme 4). We
hypothesize that this unusual reactivity is due to the (−I)-effect
of the fluorine substituent, further depleting the electronic
density of carbocation II and creating additional demand for
nucleophilic solvent participation. To confirm this hypothesis,
we computed the natural atomic charges on the halogens and
the cationic carbon atom using NBO (natural bond orbital)
analysis for the B3LYP/6-311+G(d,p) geometries of the
halogen-stabilized cations as exemplified by the model
intermediate IXa−f (Table 2).
According to the literature data,8−11 the most likely scenario
for the subsequent step is the intramolecular cyclization of
carbocation II, yielding the isoxazole moiety shown in Scheme
5. Indeed, we have found that the reaction of gem-
dihalogenobicycloheptanes 1b−d with NOBF4 led to the
corresponding 5-halogenoisoxazoles 2b,c. In the case of the
compound 1c, the only product of the reaction was 5-
chloroisoxazole 2c, and no 5-bromoisoxazole 2b was observed,
C
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Note
MHz, CDCl3) δ: (E-6b + Z-6b) 0.83−0.90 (m, 3H, CH3, Z-6b + 3H,
CH3, E-6b), 1.04−1.12 (m, 1H Z-6b + 1H E-6b, CH2), 1.22−1.62 (m,
28 H). 13C NMR (100 MHz, CDCl3) δ: (E-6b + Z-6b) 14.0 (CH3, Z-
6b + CH3, E-6b), 22.2 (JCF = 10 Hz, CH2), 22.6 (CH2, Z-6b +CH2, E-
6b), 22.6 (JCF = 10 Hz, CH2), 25.7 (JCF = 9 Hz, CH), 27.2 (JCF = 5 Hz,
As follows from Table 2, the carbocation bearing one or two
fluorine atoms carries much higher positive charge on the
carbon atom, 0.53 (FBr), 0.54 (FCl), 1.09 (F2), in comparison
with the species lacking fluorine. For bromo- or chloro-
substituted carbocations, most of the positive charge is
delocalized on the halogens, with carbon carrying little charge
(−0.04, +0.004, +0.06). There is an energy penalty for this
charge localization, but it is rather small: carbocation IXd,
which is stabilized by Cl and Br, is only 2.7 kcal/mol more
stable than cation IXc (F-, Br-stabilized). Yet IXc has
significantly more positive carbon atom. Such atomic charge
distribution can explain the high demand for solvent
participation in intramolecular cyclization of fluorinated
carbocations II (Scheme 4). This is in keeping with the
observation that Ritter-like trapping of nitriles occurs in other
heteroatom-stabilized carbocationic intermediates.36 In general,
the transformations II → V (Scheme 4) can be interpreted as a
1,4-dipolar addition to a triple bond, which is followed by the
loss of a proton and elimination of HBr to yield the resulting
pyrimidine N-oxide VII.
CH2), 28.2 (JCF = 1 Hz, CH2), 28.79, 28.81, 28.9 (CH2), 29.1 (JCF
=
11 Hz, CH), 31.6 (JCF = 1 Hz, CH2), 31.65, 31.67 (CH2), 82.6 (JCF
=
302 Hz, CBrF), 87.9 (JCF = 298 Hz, CBrF). 19F NMR (376 MHz,
CDCl3) δ: (E-6b) −148.6 to −148.7 (m, 1F); (Z-6b) −126.3 to
−126.4 (m, 1F). MS (EI) m/z: 224 (0.03), 222 (0.03) [M]+, 140 (1),
139 (5), 138 (1), 137 (5) [M − C6H13]+. Anal. Calcd for C9H16BrF:
C, 48.45; H, 7.23. Found: C, 48.80; H, 7.09.
[(2-Bromo-2-fluorocyclopropyl)methyl]benzene (6c). Yield: 1.28 g
1
(51%), E/Z = 1:2. Colorless liquid. Rf = 0.5 (petroleum ether). H
2
3
NMR (400 MHz, C6D6) δ: (E-6c) 0.75 (ddd, JHH = 7.8 Hz, JHH
7.8 Hz, 3JHF = 17.5 Hz, 1H, Hb, CH2, cy-Pr), 0.91 (ddd, 2JHH = 7.8 Hz,
3JHH =10.8 Hz, 3JHF = 7.7 Hz, 1H, Ha, CH2, cy-Pr), 1.38 (dddd, 3JHH
10.8 Hz, 3JHH = 7.8 Hz, 3JHH = 7.1 Hz, 3JHF = 1.9 Hz, 1H, CH, cy-Pr),
=
=
2
3
4
2.33 (ddd, JHH = 15.3 Hz, JHH = 7.1 Hz, JHF = 1.7 Hz, 1H, CH2),
2.54 (br.dd, JHH = 15.3 Hz, 3JHH = 7.1 Hz, 1H, CH2), 6.97−7.06 (m,
2
3H, 2CH, Ph+CH, Ph), 7.07−7.13 (m, 2H, 2CH, Ph); (Z-6c) 0.53
2
3
3
(ddd, JHH = 7.5 Hz, JHH = 7.8 Hz, JHF = 7.2 Hz, 1H, Hb, CH2, cy-
Pr), 1.12 (ddd, 2JHH = 7.5 Hz, 3JHH = 11.4 Hz, 3JHF = 17.2 Hz, 1H, Ha,
CH2, cy-Pr), 1.30 (dddd, 3JHH = 7.8 Hz, 3JHH = 11.4 Hz, 3JHH = 7.2 Hz,
3JHF = 19.5 Hz, 1H, CH, cy-Pr), 2.24 (ddd, 2JHH = 15.3 Hz, 3JHH = 7.2
Hz, 4JHF = 2.9 Hz, 1H, CH2), 2.56 (br.dd, 2JHH = 15.3 Hz, 3JHH = 7.24
Hz, 1H, CH2), 6.79−7.01 (m, 2H, 2CH, Ph), 7.01−7.06 (m, 1H, CH,
Ph), 7.07−7.13 (m, 2H, 2CH, Ph). 13C NMR (100 MHz, CDCl3) δ:
(E-6c) 22.5 (JCF = 11 Hz, CH2), 29.6 (JCF = 11 Hz, CH), 33.2 (JCF = 5
Hz, CH2), 82.0 (JCF = 302 Hz, CBrF), 126.6 (CH, Ph), 128.3 (2CH,
Ph), 128.7 (2CH, Ph), 139.6 (C, Ph); (Z-6c) 22.8 (JCF = 10 Hz, CH2),
26.4 (JCF = 9 Hz, CH), 37.2 (CH2), 87.2 (JCF = 299 Hz, CBrF), 126.5
(CH, Ph), 128.4 (2CH, Ph), 128.7 (2CH, Ph), 139.2 (C, Ph). 19F
NMR (376 MHz, C6D6) δ: (E-6c) −148.1 (dddd, JHF = 17.5, 7.7, 1.9,
1.7 Hz); −127.5 (Z-6c) (dddd, JHF = 19.5, 17.2, 7.2, 2.9 Hz). MS (EI)
m/z: 230 (0.6), 228 (0.7) [M]+, 150 (12), 149 (100) [M − Br]+. Anal.
Calcd for C10H10BrF: C, 52.43; H, 4.40. Found: C, 52.41; H, 4.60.
1-(2-Bromo-2-fluorocyclopropyl)-3-chlorobenzene (6e). Yield:
1.70 g (62%), E/Z = 1:0.8. Colorless liquid. Rf = 0.4 (petroleum
In conclusion, we have developed a simple and efficient
synthesis of previously unknown 4-fluoropyrimidine N-oxides
based on heterocyclization of readily available 1-bromo-1-
fluorocyclopropanes upon treatment with commercial NOBF4
in the presence of nitriles as solvents. The reaction underlines a
fine balance of effects, including the fluorine electronegativity,
determining the outcome of such heterocyclizations.
EXPERIMENTAL SECTION
■
1H, 13C, and 19F NMR spectra were recorded on a 400 MHz
spectrometer (400.0, 100.6, and 376.3 MHz for 1H, 13C, and 19F,
respectively) at room temperature; chemical shifts δ were measured
1
with reference to the solvent for H (CDCl3, δ = 7.24 ppm) and 13C
(CDCl3, δ = 77.13 ppm) and to CFCl3 as an external standard for 19F.
1
Assignment of signals in NMR H spectra were made using COSY
experiments and a spin simulation technique. Mass spectra were taken
on a 70 eV spectrometer using electron-impact ionization (EI) and
GC−MS coupling. Accurate mass measurements (HRMS) were
measured on an electrospray ionization (ESI) instrument with a
time-of-flight (TOF) detector. Analytical thin-layer chromatography
was carried out with silica gel plates (supported on aluminum) or
aluminum oxide plates (supported on aluminum); the detection was
done by UV lamp (254 and 365 nm) and chemical staining (iodine
vapor). Column chromatography was performed on silica gel (230−
400 mesh) or aluminum oxide (neutral, 50−200 μm). Starting
compounds: 7-bromo-7-fluorobicyclo[4.1.0]heptane (1a),37 7,7-di-
bromobicyclo[4.1.0]heptane (1b),38 7-bromo-7-chlorobicyclo[4.1.0]-
heptane (1c),39 1-bromo-2-butyl-1-fluorocyclopropane (6a),40 and (2-
bromo-2-fluorocyclopropyl)benzene (6d)37 were synthesized by
known procedures. All other starting materials were commercially
available. All reagents except commercial products of satisfactory
quality were purified by literature procedures prior to use. All reactions
were carried out under argon atmosphere and stirred magnetically.
General Procedure for Synthesis of gem-Bromofluorocyclo-
propanes. A 50% aqueous solution of NaOH (22 mL) was added
dropwise to a stirred mixture of the corresponding alkene (11.0
mmol), CHBr2F (2.53 g, 13.2 mmol), and TEBAC (0.1 g, 0.04 mmol)
in dichloromethane (20 mL) at 0 °C. The reaction mixture was
warmed to room temperature and stirred for 72 h. It was then treated
with ice (20 g). The organic phase was separated and the water phase
extracted with dichloromethane (3 × 10 mL). The combined organic
layers were washed with water (50 mL) and dried over MgSO4. The
solvent was evaporated in vacuo; the residue was purified by
preparative column chromatography on silica gel using petroleum
ether (or petroleum ether/ethyl acetate (5:1) for the compound 6f).
1-Bromo-1-fluoro-2-hexylcyclopropane (6b). Yield: 1.81 g (74%),
E/Z = 1:1. Colorless liquid. Rf = 0.6 (petroleum ether). 1H NMR (400
1
2
ether). H NMR (400 MHz, CDCl3) δ: (E-6e) 1.87 (ddd, JHH = 8.3
Hz, 3JHH = 10.8 Hz, 3JHF = 8.9 Hz, 1H, Ha, CH2), 1.92 (ddd, 2JHH3 = 8.3
Hz, JHH = 8.2 Hz, JHF = 17.6 Hz, 1H, Hb, CH2), 2.79 (ddd, JHH
=
3
3
3
3
10.8 Hz, JHH = 8.2 Hz, JHF = 2.4 Hz, 1H, CH), 7.11−7.15 (m, 1H,
CH, Ar), 7.21−7.23 (m, 1H, CH, Ar), 7.26−7.32 (m, 2H, CH, Ar);
(Z-6e) 1.69 (ddd, 2JHH = 8.2 Hz, 3JHH = 8.5 Hz, 3JHF = 7.3 Hz, 1H, Hb,
2
3
3
CH2), 2.08 (ddd, JHH = 8.2 Hz, JHH = 11.6 Hz, JHF = 16.9 Hz, 1H,
Ha, CH2), 2.78 (ddd, JHH = 11.6 Hz, JHH = 8.5 Hz, JHF = 17.7 Hz,
1H, CH), 7.14−7.18 (m, 1H, CH, Ar), 7.26−7.32 (m, 3H, CH, Ar).
13C NMR (100 MHz, CDCl3) δ: (E-6e) 23.1 (JCH = 165 Hz, JCF = 10
Hz, CH2), 32.7 (JCH = 164 Hz, JCF = 11 Hz, CH), 79.8 (JCF = 302 Hz,
CBrF), 126.5 (JCH = 164 Hz, JCF = 1 Hz, CH, Ar), 127.5 (JCH = 167
Hz, CH, Ar), 128.5 (JCH = 164 Hz, CH, Ar), 129.6 (JCH = 164 Hz, CH,
Ar), 134.3 (CCl), 135.7 (JCF = 2 Hz, C, Ar); (Z-6e) 22.0 (JCH = 165
Hz, JCF = 11 Hz, CH2), 30.1 (JCH = 162 Hz, JCF = 11 Hz, CH), 85.3
(JCF = 302 Hz, CBrF), 126.9 (JCH = 164 Hz, JCF = 2 Hz, CH, Ar),
127.6 (JCH = 167 Hz, CH, Ar), 128.7 (JCH = 164 Hz, JCF = 3 Hz, CH,
Ar), 129.7 (JCH = 164 Hz, CH, Ar), 133.4 (CCl, Ar), 137.6 (C, Ar).
19F NMR (376 MHz, CDCl3) δ: (E-6e) −146.75 (ddd, 3JHF = 16.8 Hz,
3
3
3
3JHF = 9.6 Hz, JHF = 2.4 Hz, 1F); (Z-6e) −125.67 (ddd, JHF = 17.6
3
3
3
3
Hz, JHF = 16.8 Hz, JHF = 7.2 Hz, 1F). MS (EI) m/z: 252 (0.5), 251
(0.2), 250 (2), 249 (0.2), 248 (2) [M]+, 172 (3), 171 (34), 170 (11),
169 (100) [M − Br]+. Anal. Calcd for C9H7BrClF: C, 43.32; H, 2.83.
Found: C, 43.25; H, 2.95.
1-(2-Bromo-2-fluorocyclopropyl)-3-nitrobenzene (6f). Yield: 1.20
g (42%), E/Z = 0.8:1. Colorless liquid. Rf = 0.5 (petroleum ether/ethyl
acetate 5:1). 1H NMR (400 MHz, CDCl3) δ: (E-6f) 1.96 (ddd, 2JHH br
3
3
s = 8.3 Hz, JHH = 10.8 Hz, JHF = 9.2 Hz, 1H, Ha, CH2), 2.00 (ddd,
2JHH = 8.3 Hz, 3JHH = 8.4 Hz, 3JHF = 17.5 Hz, 1H, Hb, CH2), 2.88 (ddd,
3JHH = 10.8 Hz, 3JHH = 8.4 Hz, 3JHF = 2.6 Hz, 1H, CH), 7.53 (pseudo t,
D
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Note
3JHH = 8.1 Hz, 1H, CH, Ar), 7.60−7.63 (m, 1H, CH, Ar), 8.11 (br s,
(376 MHz, CDCl3) δ: −74.64 (s, 1F). HRMS: calcd for C9H11FN2O
[M + H]+ 183.0934, found 183.0965.
2
1H, CH, Ar), 8.12−8.16 (m, 1H, CH, Ar); (Z-6f) 1.79 (ddd, JHH
=
=
8.3 Hz, 3JHH = 8.5 Hz, 3JHF = 7.2 Hz, 1H, Hb, CH2), 2.18 (ddd, 2JHH
2-Ethyl-4-fluoro-5,6,7,8-tetrahydroquinazoline 1-Oxide (3b).
1
8.3 Hz, 3JHH = 11.4 Hz, 3JHF3 = 16.7 Hz, 1H, Ha, CH2), 2.93 (ddd, 3JHH
Yield: 0.18 g (46%). Light yellow oil. Rf = 0.3 (CHCl3). H NMR
3
3
(400 MHz, CDCl3) δ: 1.23 (t, JHH = 7.5 Hz, 3H, CH3), 1.68−1.75
= 11.4 Hz, JHH = 8.5 Hz, JHF = 17.2 Hz, 1H, CH), 7.55 (pseudo t,
3JHH = 8.1 Hz, 1H, CH, Ar), 7.58−7.61 (m, 1H, CH, Ar), 8.07 (br s,
(m, 2H, CH2, cy-Hex), 1.81−1.88 (m, 2H, CH2, cy-Hex), 2.61 (br t,
3JHH = 6.2 Hz, 2H, CH2, cy-Hex), 2.85 (br t, 3JHH = 6.4 Hz, 2H, CH2,
1H, CH, Ar), 8.14−8.18 (m, 1H, CH, Ar). 13C NMR (100 MHz,
3
cy-Hex), 2.98 (q, JHH = 7.5 Hz, 2H, CH2, Et). 13C NMR (100 MHz,
CDCl3) δ: (E-6f) 23.1 (JCH = 165 Hz, JCF = 11 Hz, CH2), 32.5 (JCH
=
CDCl3) δ: 9.1 (JCH = 129 Hz, JCH = 5 Hz, CH3), 20.2 (JCH = 130 Hz,
CH2, cy-Hex), 20.7 (JCH=131 Hz, CH2, cy-Hex), 21.0 (JCH=131 Hz,
JCF = 3 Hz, CH2, cy-Hex), 24.9 (JCH = 130 Hz, JCF = 5 Hz, CH2, Et),
25.2 (JCH = 132 Hz, JCF = 3 Hz, CH2, cy-Hex), 115.5 (JCF = 36 Hz, C−
CC), 155.4 (JCF = 248 Hz, CF), 159.0 (JCF = 16 Hz, N−CN),
159.4 (JCF = 7 Hz, C−CN). 19F NMR (376 MHz, CDCl3) δ:
−74.56 (s, 1F). HRMS: calcd for C10H13FN2O [M + H]+ 197.1085,
found 197.1086.
165 Hz, JCF = 11 Hz, CH), 79.3 (JCF 301 Hz, CBrF), 122.4 (JCH = 169
Hz, CH, Ar), 123.2 (JCH = 167 Hz, JCF = 1 Hz, CH, Ar), 129.4 (JCH
=
165 Hz, CH, Ar), 134.5 (JCH = 162 Hz, JCF = 1 Hz, CH, Ar), 135.8
(JCF = 2 Hz, C, Ar), 148.3 (C-NO2, Ar); (Z-6f) 22.3 (JCH = 165 Hz,
JCF = 11 Hz, CH2), 30.0 (JCH = 162, JCF = 12, CH), 84.7 (JCF = 303
Hz, CBrF), 122.5 (JCH = 167 Hz, CH, Ar), 123.4 (JCH = 169 Hz, JCF
=
2 Hz, CH, Ar), 129.4 (JCH = 165 Hz, CH, Ar), 134.9 (JCH = 162 Hz,
JCF = 2 Hz, CH, Ar), 137.7 (C, Ar), 148.3 (C-NO2, Ar). 19F NMR
3
3
2-tert-Butyl-4-fluoro-5,6,7,8-tetrahydroquinazoline 1-Oxide (3c).
Yield: 0.27 g (62%). Light yellow oil. Rf = 0.4 (CHCl3). 1H NMR (400
MHz, CDCl3) δ: 1.49 (s, 9H, 3CH3), 1.73−1.80 (m, 2H, CH2), 1.84−
(376 MHz, CDCl3) δ: (Z-6f) −126.46 (ddd, JHF = 17.2 Hz, JHF
=
16.7 Hz, 3JHF = 7.2 Hz, 1F); (E-6f) −147.16 (ddd, 3JHF = 17.5 Hz, 3JHF
= 9.2 Hz, 3JHF = 2.6 Hz, 1F). MS (EI, 70 eV) m/z: 261 (0.3), 259 (0.3)
[M]+, 181 (3), 180 (24) [M − Br]+. Anal. Calcd for C9H7BrFNO2: C,
41.57; H, 2.71; N, 5.39. Found: C, 41.44; H, 2.75; N, 5.20.
3
1.92 (m, 2H, CH2), 2.65 (br t, JHH = 6.2 Hz, 2H, CH2), 2.88 (br t,
3JHH = 6.5 Hz, 2H, CH2). 13C NMR (100 MHz, CDCl3) δ: 20.2
(CH2), 20.9 (CH2), 21.2 (JCF = 3 Hz, CH2), 25.3 (JCF = 3 Hz, CH2),
26.1 (3CH3), 38.3 (C, t-Bu), 116.0 (JCF = 37 Hz, C−CC), 154.4
(JCF = 246 Hz, CF), 161.0 (JCF = 7 Hz, C−CN), 162.1 (JCF = 16 Hz,
N−CN). 19F NMR (376 MHz, CDCl3) δ: −74.80 (s, 1F). HRMS:
calcd for C12H17FN2O [M + H]+ 225.1398, found 225.1405.
1-(2-Bromo-2-fluorocyclopropyl)-2-fluorobenzene (6g). Yield:
1.64 g (64%), E/Z = 0.6:1. Colorless liquid. Rf = 0.4 (petroleum
1
2
ether). H NMR (400 MHz, C6D6) δ: (E-6g) 1.16 (ddd, JHH = 8.1
Hz, 3JHH = 11.1 Hz, 3JHF = 8.9 Hz, 1H, Ha, CH2), 1.29 (ddd, 2JHH3 = 8.1
Hz, JHH = 8.3 Hz, JHF = 17.5 Hz, 1H, Hb, CH2), 2.47 (ddd, JHH
=
3
3
4-Fluoro-2-phenyl-5,6,7,8-tetrahydroquinazoline 1-Oxide (3d).
3
3
11.1 Hz, JHH = 8.3 Hz, JHF = 1.8 Hz, 1H, CH), 6.60−6.81 (m, 4H,
1
Yield: 0.10 g (20%). Light yellow oil. Rf = 0.2 (CHCl3). H NMR
2
3
3
CH, Ar); (Z-6g) 1.12 (ddd, JHH = 8.0 Hz, JHH = 8.6 Hz, JHF = 7.1
(400 MHz, CDCl3) δ: 1.79−1.85 (m, 2H, CH2), 1.90−1.98 (m, 2H,
Hz, 1H, Hb, CH2), 1.36 (ddd, JHH = 8.0 Hz, JHH = 11.6 Hz, JHF
=
2
3
3
3
3
CH2), 2.73 (br t, JHH = 6.4 Hz, 2H, CH2), 2.98 (br t, JHH = 6.4 Hz,
2H, CH2), 7.44−7.50 (m, 3H, 3CH, Ph), 8.54−8.59 (m, 2H, 2CH,
Ph). 13C NMR (100 MHz, CDCl3) δ: 20.2 (CH2), 20.9 (CH2), 21.4
(JCF = 3 Hz, CH2), 25.5 (JCF = 3 Hz, CH2), 116.7 (JCF = 36 Hz, C−
CC), 128.0 (2CH, Ph), 130.0 (2CH, Ph), 131.0 (C, Ph), 131.3
(CH, Ph), 151.3 (JCF = 17 Hz, N−CN), 155.1 (JCF = 246 Hz, CF),
161.6 (JCF = 7 Hz, C−CN). 19F NMR (376 MHz, CDCl3) δ:
−73.46 (s, 1F). HRMS: calcd for C14H13FN2O [M + H]+ 245.1085,
found 245.1097.
16.6 Hz, 1H, Ha, CH2), 2.47 (ddd, 3JHH = 8.6 Hz, 3JHH = 11.6 Hz, 3JHF
= 17.6 Hz, 1H, CH), 6.48−6.54 (m, 1H, CH, Ar), 6.60−6.81 (m, 3H,
CH, Ar). 13C NMR (100 MHz, CDCl3) δ: (E-6g) 22.0 (JCF = 11 Hz,
JCF = 1 Hz, CH2), 27.1 (JCF = 11 Hz, JCF = 4 Hz, CH), 79.9 (JCF = 301
Hz, JCF = 1 Hz, CBrF), 115.4 (JCF = 22 Hz, CH, Ar), 121.0 (JCF = 15
Hz, JCF = 3 Hz, C, Ar), 124.0 (JCF = 4 Hz, CH, Ar), 129.0 (JCF = 3 Hz,
JCF = 2 Hz, CH, Ar), 129.1 (JCF = 9 Hz, CH, Ar), 162.3 (JCF = 247 Hz,
CF, Ar); (Z-6g) 21.4 (JCF = 11 Hz, JCF = 1 Hz, CH2), 25.2 (JCF = 12
Hz, JCF = 3 Hz, CH), 85.1 (JCF = 302 Hz, JCF = 2 Hz, CBrF), 115.3
(JCF = 22 Hz, CH, Ar), 123.1 (JCF = 15 Hz, JCF = 1 Hz, C, Ar), 123.9
(JCF = 4 Hz, CH, Ar), 129.1 (JCF = 4 Hz, JCF = 4 Hz, CH, Ar), 129.2
(JCF = 8 Hz, CH, Ar), 162.2 (JCF = 248 Hz, CF, Ar). 19F NMR (376
MHz, CDCl3) δ: (Z-6g) −116.21 to −116.31 (m, 1F, Ar), −127.04
(ddd, 3JHF = 7.1 Hz, 3JHF = 16.6 Hz, 3JHF = 17.6 Hz, 1F, cy-Pr); (E-6g)
6-Butyl-4-fluoro-2-methylpyrimidine 1-Oxide (7a). Yield: 0.16 g
(44% for the mixture of 7a and 8a isomers in 3:1 ratio). Light yellow
oil. Rf = 0.3 (CHCl3). 1H NMR (400 MHz, CDCl3) δ: 0.95−1.05 (m,
3H, CH3, Bu), 1.41−1.50 (m, 2H, CH2, Bu), 1.63−1.72 (m, 2H, CH2,
Bu), 2.69 (s, 3H, CH3), 2.91 (t, 3JHH = 7.8 Hz, 2H, CH2, Bu), 6.82 (d,
JHF = 3.8 Hz, 1H, CH). 13C NMR (100 MHz, CDCl3) δ: 13.7 (CH3,
Bu), 20.0 (CH3), 22.3 (CH2), 27.3 (CH2), 30.6 (JCF = 2 Hz, CH2),
104.2 (JCF = 39 Hz, CH), 156.8 (JCF = 250 Hz, CF), 159.1 (JCF = 17
Hz, N−CN), 163.8 (JCF = 8 Hz, C−CN). 19F NMR (376 MHz,
CDCl3) δ: −68.98 (br s, 1F). HRMS: calcd for C9H13FN2O [M + H]+
185.1085, found 185.1092. 5-Butyl-4-fluoro-2-methylpyrimidine 1-
Oxide (8a). 1H NMR (400 MHz, CDCl3) δ: 0.95−1.05 (m, 3H, CH3,
−116.44 to −116.53 (m, 1F, Ar), −145.57 (ddd, 3JHF = 8.9 Hz, 3JHF
=
17.5 Hz, 3JHF = 1.8 Hz, 1F, cy-Pr). MS (EI, 70 eV) m/z: 234 (0.6), 232
(0.6) [M]+, 154 (7), 153 (73) [M − Br]+. Anal. Calcd for C9H7BrF2:
C, 46.38; H, 3.03. Found: C, 46.01; H, 2.96.
General Procedure for Reaction of gem-Dihalogenocyclo-
propanes with NOBF4. NOBF4 (0.28 g, 2.4 mmol) was added to the
solution of gem-dihalogenocyclopropane (2.0 mmol) in 2 mL of the
corresponding nitrile. The reaction mixture was stirred for 5 h at 80 °C
for alkyl-substituted cyclopropanes 1a−c and 6a,b or for 24−72 h at rt
for aryl-substituted cyclopropanes 6d−g. It was then was treated with
an equal amount of water. The organic phase was separated and the
water phase extracted with chloroform (3 × 2 mL). The combined
organic layers were washed with water (3 × 2 mL) and dried over
MgSO4. The solvent was evaporated in vacuo; the residue was purified
by preparative column chromatography on silica gel (for isoxazoles) or
aluminum oxide (for pyrimidine N-oxides), using chloroform as the
eluent.
3
Bu), 1.48−1.62 (m, 4H, 2CH2, Bu), 2.54 (t, JHH = 7.8 Hz, 2H, CH2,
Bu), 2.63 (s, 3H, CH3), 8.32 (d, JHF = 7.8 Hz, 1H, CH). 13C NMR
(100 MHz, CDCl3) δ: 13.8 (CH3, Bu), 19.0 (CH3), 22.6 (CH2), 26.8
(CH2), 30.2 (CH2), 121.5 (JCF = 35 Hz, C−CN), 148.3 (JCF = 6 Hz,
CH), 156.5 (JCF = 17 Hz, N−CN), 156.7 (JCF = 251 Hz, CF). 19F
4
NMR (376 MHz, CDCl3) δ: −72.49 (d, JHF = 7.8 Hz, 1F).
4-Fluoro-6-hexyl-2-methylpyrimidine 1-Oxide (7b). Yield: 0.24 g
(57%). Light yellow oil. Rf = 0.3 (CHCl3). 1H NMR (400 MHz,
CDCl3) δ: 0.82−0.91 (m, 5H, CH2 + CH3), 1.45−1.54 (m, 4H, CH2),
3
1.65−1.75 (m, 2H, 2CH2), 2.70 (s, 3H, CH3), 2.91 (t, JHH = 7.8 Hz,
2H, CH2), 6.82 (3JHF = 4.1 Hz, 1H, CH). 13C NMR (100 MHz,
CDCl3) δ: 14.0 (CH3, Bu), 20.0 (CH3), 22.4 (CH2), 28.9 (CH2), 30.9
(JCF = 3 Hz, CH2), 31.4 (CH2), 31.6 (CH2), 104.1 (JCF = 39 Hz, CH),
157.1 (JCF = 250 Hz, CF), 159.2 (JCF = 17 Hz, N−CN), 164.0 (JCF
4-Fluoro-2-methyl-5,6,7,8-tetrahydroquinazoline 1-Oxide (3a).
1
Yield: 0.17 g (47%). Light yellow oil. Rf = 0.3 (CHCl3). H NMR
(400 MHz, CDCl3) δ: 1.76−1.84 (m, 2H, CH2), 1.88−1.97 (m, 2H,
CH2), 2.68 (s, 3H, CH3), 2.70 (br t, 3JHH = 6.4 Hz, 2H, CH2), 2.94 (br
t, 3JHH = 6.5 Hz, 2H, CH2). 13C NMR (100 MHz, CDCl3) δ: 19.5 (JCH
= 131 Hz, CH3), 20.2 (JCH =131 Hz, CH2), 20.7 (JCH = 131 Hz, CH2),
21.1 (JCH = 131 Hz, JCF = 2 Hz, CH2), 25.2 (JCH = 131 Hz, JCF = 3 Hz,
CH2), 116.0 (JCF = 36 Hz, C−CC), 155.2 (JCF = 248 Hz, CF), 155.4
(JCF = 17 Hz, N−CN), 159.6 (JCF = 7 Hz, C−CN). 19F NMR
= 8 Hz, C−CN). 19F NMR (376 MHz, CDCl3) δ: −69.68 (d, 3JHF
=
4.1 Hz, 1F). HRMS: calcd for C11H17FN2O [M + H]+ 213.1397, found
213.1398. 4-Fluoro-5-hexyl-2-methylpyrimidine 1-Oxide (8b).41 1H
NMR (400 MHz, CDCl3) δ: 0.75−0.90 (m, 5H, CH2 + CH3), 1.47−
1.60 (m, 4H, CH2), 1.60−1.71 (m, 2H, 2CH2), 2.65 (s, 3H, CH3),
2.71 (t, 3JHH = 7.5 Hz, 2H, CH2), 8.37 (d, 2JCH = 8.0 Hz, 1H, CHpyr).
E
dx.doi.org/10.1021/jo301880m | J. Org. Chem. XXXX, XXX, XXX−XXX

The Journal of Organic Chemistry
Note
13C NMR (101 MHz, CDCl3) δ: 13.9 (CH3, Bu), 19.5 (CH3), 22.3
(CH2), 28.6 (CH2), 31.1 (4JCF = 3 Hz, CH2), 31.2 (CH2), 31.7 (CH2),
121.7 (2JCF = 34 Hz, C−CN), 148.5 (3JCF = 6 Hz, CHpyr), 156.54
(3JCF = 18 Hz, N−CN), 156.55 (1JCF = 252 Hz, CF). 19F NMR (376
MHz, CDCl3) δ: −71.51 (br s, 1F).
4-Fluoro-2-methyl-6-phenylpyrimidine 1-Oxide (7d). Yield: 0.16 g
(39%). Light yellow oil. Rf = 0.3 (CHCl3). 1H NMR (400 MHz,
CDCl3) δ: 2.75 (s, 3H, CH3), 7.03 (d, JHF = 3.9 Hz, 1H, CH), 7.47−
7.55 (m, 3H, 3CH, Ph), 7.89−7.95 (m, 2H, 2CH, Ph). 13C NMR (100
MHz, CDCl3) δ: 20.4 (CH3), 105.3 (JCF = 40 Hz, CH), 128.5 (2CH,
Ph), 129.2 (2CH, Ph), 130.2 (JCF = 3 Hz, C, Ph), 131.4 (CH, Ph),
ethanol). 1H NMR (400 MHz, CD3OD) δ: 1.79−1.88 (m, 2H, CH2),
1.92−1.99 (m, 2H, CH2), 2.41−2.51 (m, 2H, CH2), 2.60−2.95 (br m,
2H, CH2), 3.36 (s, 3H, CH3).
4-Fluoro-2-methyl-5,6,7,8-tetrahydroquinazoline 1-Oxide Picrate
(5). Compound 5 was obtained via described method43 as yellow
1
crystals. Mp: 105−107 °C (crystallized from ethanol). H NMR (400
MHz, CDCl3) δ: 1.78−2.01 (m, 4H, 2CH2), 2.75 (t, JHH = 5.8 Hz, 2H,
CH2), 2.78 (s, 3H, CH3), 3.07 (t, JHH = 6.3 Hz, 2H, CH2), 9.01 (s, 2H,
2CH, Ar). 13C NMR (100 MHz, CDCl3) δ: 19.8 (CH2), 19.9 (CH3),
20.3 (CH2), 21.1 (JCF = 2 Hz, CH2), 25.5 (JCF = 2 Hz, CH2), 117.7
(JCF = 34 Hz, C−CC), 126.1 (2CH, Ar), 135.2 (CNO2), 138.9
(2CNO2), 155.6 (C−OH), 158.7 (JCF = 19 Hz, N−CN), 159.7 (JCF
= 256 Hz, CF), 162.7 (JCF = 9 Hz, C−CN). 19F NMR (376 MHz,
CDCl3) δ: −63.50 (s, 1F).
156.7 (JCF = 249 Hz, CF), 157.9 (JCF = 8 Hz, C−CN), 160.5 (JCF
3.9 Hz, 1F). HRMS: calcd for C11H9FN2O [M + H]+ 205.0772, found
205.0777.
=
=
17 Hz, N−CN). 19F NMR (376 MHz, CDCl3) δ: −70.08 (d, 3JHF
ASSOCIATED CONTENT
* Supporting Information
6-(3-Chlorophenyl)-4-fluoro-2-methylpyrimidine 1-Oxide (7e).
■
1
Yield: 0.18 g (53%). Light yellow oil. Rf = 0.3 (CHCl3). H NMR
S
(400 MHz, CDCl3) δ: 2.76 (s, 3H, CH3), 7.03 (d, JHF = 3.9 Hz, 1H,
CH), 7.45−7.53 (m, 2H, 2CH, Ar), 7.77−7.80 (m, 1H, CH, Ar), 7.98
(br s, 1H, CH, Ar). 13C NMR (100 MHz, CDCl3) δ 20.4 (CH3), 105.6
(JCF = 40 Hz, CH), 127.4 (CH, Ar), 129.2 (CH, Ar), 129.9 (CH, Ar),
131.3 (C, Ar), 131.6 (CH, Ar), 134.6 (CCl), 156.8 (JCF = 8 Hz, C−
X-ray data for compounds 4 and 5. Tables of atomic
coordinates and absolute energies and details of calculations.
1H, 13C and 19F NMR spectra of the reported compounds. This
material is available free of charge via the Internet at http://
pubs.acs.org.
CN), 157.3 (JCF = 250 Hz, CF), 161.0 (JCF = 18 Hz, N−CN). 19
F
3
NMR (376 MHz, CDCl3) δ: −69.55 (d, JHF = 3.9 Hz, 1F). HRMS:
calcd for C11H8ClFN2O [M + H]+ 239.0382, found 239.0391.
4-Fluoro-6-(3-nitrophenyl)-2-methylpyrimidine 1-Oxide (7f).
Yield: 0.24 g (48%). Light yellow solid. Mp: 114−116 °C (crystallized
from chloroform). Rf = 0.1 (CHCl3). 1H NMR (400 MHz, CDCl3) δ:
2.77 (s, 3H, CH3), 7.12 (d, JHF = 4.1 Hz, 1H, CH), 7.69−7.73 (m, 1H,
CH, Ar), 8.30 (d, JHH = 7.9 Hz, 1H, CH, Ar), 8.38 (br.d, JHH=8.2 Hz,
1H, CH, Ar), 8.80 (br s, H, CH, Ar). 13C NMR (100 MHz, CDCl3) δ:
20.3 (CH3), 105.5 (JCF = 40 Hz, CH), 124.4 (CH, Ar), 126.0 (CH,
Ar), 129.7 (CH, Ar), 131.6 (C, Ar), 135.0 (JCF = 3 Hz, CH, Ar), 148.1
(CNO2, Ar), 155.2 (JCF = 7 Hz, C−CN), 156.6 (JCF = 250 Hz, CF),
161.0 (JCF = 17 Hz, N−CN). 19F NMR (376 MHz, CDCl3) δ:
AUTHOR INFORMATION
Corresponding Author
*E-mail: elaver@org.chem.msu.ru, andrei.kutateladze@du.edu.
■
Notes
The authors declare no competing financial interest.
ACKNOWLEDGMENTS
■
We thank the Russian Foundation for Basic Research (Project
11-03-01040-a) and the Presidium of RAS (Program No. 8) for
financial support of this work. The research work was carried
out using an equipment diffractometer STADI VARI Pilatus-
100K and an NMR spectrometer Agilent 400-MR, purchased
under the program of MSU development. A.G.K. thanks NSF
(CHE-1057800) for partial support of this research.
3
−68.57 (d, JHF = 4.1 Hz, 1F). HRMS: calcd for C11H8FN3O3 [M +
H]+ 250.0622, found 250.0618.
4-Fluoro-6-(2-fluorophenyl)-2-methylpyrimidine 1-Oxide (7g).
1
Yield: 0.19 g (43%). Light yellow oil. Rf = 0.3 (CH2Cl2). H NMR
(400 MHz, CDCl3) δ: 2.73 (s, 3H, CH3), 7.04 (d, JHF = 4.4 Hz, 1H,
CH), 7.15−7.21 (m, 1H, Ar), 7.46−7.54 (m, 1H, Ar), 7.65−7.71 (m,
1H, Ar), 7.96−8.02 (m, 1H, Ar). 13C NMR (100 MHz, CDCl3) δ: 20.3
(CH3), 107.3 (JCF = 39 Hz, JCF = 3 Hz, CH), 116.2 (JCF = 21 Hz, CH,
Ar), 118.5 (JCF = 14 Hz, C, Ar), 124.3 (JCF = 3 Hz, CH, Ar), 130.8
(CH, Ar), 133.3 (JCF= 8 Hz, CH, Ar), 154.7 (JCF = 7 Hz, C−CN),
156.6 (JCF = 251 Hz, CF), 159.7 (JCF = 252 Hz, CF), 160.5 (JCF = 17
Hz, N−CN). 19F NMR (376 MHz, CDCl3) δ: −69.26 (d, 3JHF = 4.4
Hz, 1F, CFpyr), −111.08 to −111.25 (m, 1F, Ar). HRMS: calcd for
C11H8F2N2O [M + H]+ 223.0677, found 223.0677.
REFERENCES
■
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1
ether/ethyl acetate 5:1). H NMR (400 MHz, CDCl3) δ: 1.72−1.85
3
3
(8) Lin, S.-T.; Lin, L.-H.; Yao, Y.-F. Tetrahedron Lett. 1992, 33,
(m, 4H, 2CH2), 2.42 (t, JHH = 6.3 Hz, 2H, CH2), 2.73 (t, JHH = 6.3
Hz, 2H, CH2). 13C NMR (100 MHz, CDCl3) δ: 19.0 (CH2), 21.8
(CH2), 22.1 (CH2), 22.2 (CH2), 114.7 (C), 136.6 (CBr), 162.9
(CN). HRMS: calcd for C7H8BrNO [M + H]+ 201.9862, found
201.9866.
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3-Chloro-4,5,6,7-tetrahydro-2,1-benzisoxazole (2c). Compound
2c was obtained from 7-bromo-7-chlorobicyclo[4.1.0]heptane (1c).
Yield: 0.20 g (63%). Colorless crystals. Mp: 46−48 °C (crystallized
from petroleum ether). Rf = 0.4 (petroleum ether/ethyl acetate 5:1).
1H NMR (400 MHz, CDCl3) δ: 1.71−1.84 (m, 4H, 2 CH2), 2.45 (t,
3JHH = 6.3 Hz, 2H, CH2), 2.72 (t, 3JHH = 6.2 Hz, 2H, CH2). 13C NMR
́
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(100 MHz, CDCl3) δ: 18.5 (CH2), 22.0 (3CH2), 110.2 (C), 148.9
(CCl), 163.2 (CN). The characteristics of obtained compound
are in accord with those reported in the literature.9
Dichlorobis(4-fluoro-2-methyl-5,6,7,8-tetrahydroquinazoline 1-
oxide)copper(II) (4). Compound 4 was obtained via the described
method42 as blue crystals. Mp: 145−147 °C (crystallized from
F
dx.doi.org/10.1021/jo301880m | J. Org. Chem. XXXX, XXX, XXX−XXX

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reaction mixture of 6b with NOBF4 and was not isolated.
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G
dx.doi.org/10.1021/jo301880m | J. Org. Chem. XXXX, XXX, XXX−XXX