1404295-95-9Relevant academic research and scientific papers
Nucleophilic phosphine-catalyzed intramolecular michael reactions of N-allylic substituted α-amino nitriles: Construction of functionalized pyrrolidine rings via 5-endo-trig cyclizations
En, Da,Zou, Gong-Feng,Guo, Yuan,Liao, Wei-Wei
supporting information, p. 4456 - 4462 (2014/06/09)
Pyrrolidine rings are common moieties for pharmaceutical candidates and natural compounds, and the construction of these skeletons has received much attention. α-Amino nitriles are versatile intermediates in synthetic chemistry and have been widely used in the generation of multiple polyfunctional structures. Herein, a novel nucleophilic phosphine-catalyzed intramolecular Michael reaction of N-allylic substituted α-amino nitriles has been developed for the efficient construction of functionalized 2,4-disubstituted pyrrolidines (N-heterocyclic α-amino nitriles) via 5-endo-trig cyclization. Furthermore, the one-pot sequence of the synthesis of pyrrolidine and the subsequent transformations of the functionalized products have also been demonstrated.
Controllable regioselective construction of both functional α-methylene-β- and -γ-amino acid derivatives through an organocatalyzed tandem allylic alkylation and amination
Pan, Feng,Chen, Jian-Ming,Qin, Tian-You,Zhang, Sean Xiao-An,Liao, Wei-Wei
, p. 5324 - 5334 (2012/10/29)
A new controllable and regioselective allylic alkylation and amination reaction has been developed for the highly selective construction of compounds containing α-alkylidene-β-amino acid and α-methylene-γ- butyrolactam moieties. Furthermore, on the basis of this controllable strategy, multicomponent tandem reactions have also been accomplished. The subsequent transformations of the densely functionalized products have readily afforded a range of useful building blocks, which have potential utility in organic synthesis. Copyright
