14044-48-5Relevant articles and documents
Color tuning associated with heteroleptic cyclometalated Ir(iii) complexes: Influence of the ancillary ligand
Chang, Chau-Jiun,Yang, Cheng-Han,Chen, Kellen,Chi, Yun,Shu, Ching-Fong,Ho, Mei-Lin,Yeh, Yu-Shan,Chou, Pi-Tai
, p. 1881 - 1890 (2007)
We report the preparation of a series of new heteroleptic Ir(iii) metal complexes chelated by two cyclometalated 1-(2,4-difluorophenyl)pyrazole ligands (dfpz)H and a third ancillary bidentate ligand (L^X). Such an intricate design lies in a core concept t
Iodine-catalyzed Csp3-H functionalization of methylhetarenes: One-pot synthesis and cytotoxic evaluation of heteroarenyl-benzimidazoles and benzothiazole
Baig, Mirza Feroz,Shaik, Siddiq Pasha,Nayak, V. Lakshma,Alarifi, Abdullah,Kamal, Ahmed
, p. 4039 - 4043 (2017)
An efficient one-pot synthetic procedure has been developed for the preparation of heteroarenyl-benzimidazoles via oxidative Csp3-H functionalization with o-phenylenediamine using I2-DMSO in open air from easily available starting materials. Based on a logical plan a spectrum of multi fundamental reactions like iodination, Kornblum oxidation and amination were brought into one-pot. By using this simple method a library of heteroarenyl-benzimidazoles derivatives (3a–t and 5a–g) and heteroarenyl-benzothiazole (3u) have been synthesized in good to excellent yield and screened for their cytotoxicity against a group of four human cancer cell lines. Among them 3h, 3q and 5b showed significant cytotoxic activities with an IC50 of 1.69, 1.62 and 2.81 μM respectively against lung cancer (A549) cell line.[Figure presented]
DNA targeting half sandwich Ru(ii)-: P-cymene-N^N complexes as cancer cell imaging and terminating agents: Influence of regioisomers in cytotoxicity
Mondal, Ashaparna,Sen, Utsav,Roy, Nilmadhab,Muthukumar, Venkatesan,Sahoo, Suban Kumar,Bose, Bipasha,Paira, Priyankar
, p. 979 - 997 (2021)
For diagnosing and annihilating cancer in the human body, herein, we have adopted a one pot convenient synthetic protocol to synthesize a library of half sandwich Ru(ii)-p-cymene-N^N complexes under continuous sonication and isolated their regioisomers by
Highly selective and effective mercury(ii) fluorescent sensors
Hu, Jinghan,Li, Jianbin,Qi, Jing,Chen, Juanjuan
, p. 843 - 848 (2015)
A novel mercury non-sulfur and simple fluorescent chemosensor L based on the benzimidazole group and quinoline group as the fluorescence signal group has been designed and synthesized. The receptor could instantly detect the Hg2+ cation over other cations such as Fe3+, Ag+, Ca2+, Cu2+, Co2+, Ni2+, Cd2+, Pb2+, Zn2+, Cr3+, and Mg2+ by fluorescence spectroscopy changes in H2O/DMSO (1:9, v/v) solution with specific selectivity and high sensitivity. The fluorescence color of the solution containing sensor L showed a remarkable change from blue to colorless only after the addition of Hg2+ in aqueous media while other cations did not cause obvious color changes. Moreover, further study demonstrates that the detection limit on the fluorescence response of the sensor to Hg2+ is down to 9.56 × 10-9 M, which is far lower than the maximum level for mercury of 0.01 M in drinking water, from EPA guidelines. Test strips based on L were fabricated, which could act as convenient and efficient Hg2+ test kits. Thus, the probe should have potential applications in an aqueous environment for the monitoring of mercury.
Synthesis, X-ray structure and theoretical investigation of 2-(2’-quinolyl)benzimidazole metal complexes
Sahki, Feriel Aouatef,Messaadia, Lyamine,Merazig, Hocine,Chibani, Aissa,Bouraiou, Abdelmalek,Bouacida, Sofiane
, p. 21 - 29 (2017)
Synthesis, characterization and DFT analysis of 2-(1H-benzo[d]imidazol-2-yl)quinoline (BQ) and its cobalt and manganese coordination compounds {Co(DMF)(BQ) Cl 2} and {Mn(DMF)(BQ) Cl 2} have been described. The ligand, 2-(1H-benzo[d]imidazol-2-yl)quinoline (BQ) crystallizes in non-centrosymmetric monoclinic crystal system with cell parameters a = 12.9280(4) ?, b = 7.9429(3) ?, c = 25.8478(9) ?, α = γ=90°,β=103.005(2)°. {Co(DMF)(BQ)Cl 2} and {Mn(DMF)(BQ)Cl 2} crystallized in triclinic space group P-1. The metal(II) environment exhibits trigonal bipyramidal coordination. These complexes show presence of N–H …Cl, C–H..Cl hydrogen bonds and strong intramolecular C–H..O interactions. The structure parameters were calculated and they are in good agreement with those observed experimentally. Theoretically calculated frontier molecular orbitals (HOMO–LUMO) of the complexes and their energies indicate intermolecular charge transfer and delocalization of electron density within the molecule. [Figure not available: see fulltext.]
Iodine-imine Synergistic Promoted Povarov-Type Multicomponent Reaction for the Synthesis of 2,2′-Biquinolines and Their Application to a Copper/Ligand Catalytic System
Hu, Qi-Qi,Gao, Yan-Ting,Sun, Jia-Chen,Gao, Jing-Jing,Mu, Hong-Xiao,Li, Yi-Ming,Zheng, Ya-Nan,Yang, Kai-Rui,Zhu, Yan-Ping
, p. 9000 - 9005 (2021/11/24)
An efficient iodine-imine synergistic promoted Povarov-type multicomponent reaction was reported for the synthesis of a practical 2,2′-biquinoline scaffold. The tandem annulation has reconciled iodination, Kornblum oxidation, and Povarov aromatization, where the methyl group of the methyl azaarenes represents uniquely reactive input in the Povarov reaction. This method has broad substrate scope and mild conditions. Furthermore, these 2,2′-biquinoline derivatives had been directly used as bidentate ligands in metal-catalyzed reactions.
