1404480-10-9

Basic information

• Product Name: (E,Z)-5-bromo-2-fluoro-N-hydroxybenzimidoyl chloride
• Synonyms: (E,Z)-5-bromo-2-fluoro-N-hydroxybenzimidoyl chloride
• CAS NO: 1404480-10-9
• Molecular Weight: 252.47
• Mol File: 1404480-10-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (E,Z)-5-bromo-2-fluoro-N-hydroxybenzimidoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (E,Z)-5-bromo-2-fluoro-N-hydroxybenzimidoyl chloride(1404480-10-9)
• EPA Substance Registry System: (E,Z)-5-bromo-2-fluoro-N-hydroxybenzimidoyl chloride(1404480-10-9)

Safety Data

• Hazardous Substances Data: 1404480-10-9(Hazardous Substances Data)

Upstream product

• 93777-26-5 5-bromo-2-fluorobenzaldehyde 
• 179897-89-3 5-Bromo-2-fluoro-benzonitrile 
• 202865-65-4 C₇H₅BrFNO 

Downstream Products

• 1404480-11-0 C₁₀H₁₀BrFN₂O 
• 1404480-13-2 C₈H₈BrFN₂O 
• 1426901-61-2 3-(5-bromo-2-fluorophenyl)benzisoxazole 
• 1426902-30-8 3-[2-fluoro-5-(pyrimidin-5-yl)phenyl]benzisoxazole 
• 1426902-31-9 C₁₇H₁₀FNO₂ 
• 1426902-29-5 C₁₈H₁₁FN₂O 

Relevant articles and documents

Discovery of Natural Product-Based Fungicides (II): Semisynthesis and Biological Activity of Sarisan Attached 3-Phenylisoxazolines as Antifungal Agents

Many phytopathogenic fungi cause severe damage to crop yields. In continuation of our research aimed at the discovery and development of natural products-based fungicides, a series of thirty-one sarisan attached 3-phenylisoxazolines were synthesized and evaluated for their antifungal activities against five phytopathogenic fungi (B. cinerea, C. lagenarium, A. solani, F. solani, and F. graminearum). Among all title sarisan derivatives, compounds IV2, IV14 and IV23 showed potent antifungal activity against some phytopathogenic fungi. In particular, compound IV2 exhibited a broad-spectrum and more potent antifungal activity against A. solani, F. solani, and F. graminearum than the commercial fungicide Hymexazol. In addition, compounds IV2, IV14 and IV23 also displayed relative low toxicity on normal NRK-52E cells. This work will give some insights into the development of sarisan derivatives as new fungicide candidates in plant protection.

COMBINATION OF KINASE INHIBITORS AND USES THEREOF

The present invention provides for a method for treating a disease condition associated with PI3-kinase a and/or mTOR in a subject. In another aspect, the invention provides for a method for treating a disease condition associated with PI3-kinase a and/or mTOR in a subject. In yet another aspect, a method of inhibiting phosphorylation of both Akt (S473) and Akt (T308) in a cell is set forth. The present invention also provides a pharmaceutical kit effective for treating a disease condition associated with PI3 -kinase α and/or mTOR in a subject.

PERFLUORINATED CYCLOPROPYL FUSED 1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE

PERFLUORINATED CYCLOPROPYL FUSED 1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE ABSTRACT OF THE DISCLOSURE The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: {INSERT STRUCTURE HERE} I wherein variables A4, A5, A6, A8, each of Ra, Rb, R1, R2, R3 and R7 of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas II and III, and sub-formula embodiments thereof, intermediates and methods for preparing compounds of the invention.