1404480-13-2

Basic information

• Product Name: C₈H₈BrFN₂O
• CAS NO: 1404480-13-2
• Molecular Weight: 247.067
• Mol File: 1404480-13-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C₈H₈BrFN₂O(CAS DataBase Reference)
• NIST Chemistry Reference: C₈H₈BrFN₂O(1404480-13-2)
• EPA Substance Registry System: C₈H₈BrFN₂O(1404480-13-2)

Safety Data

• Hazardous Substances Data: 1404480-13-2(Hazardous Substances Data)

Upstream product

• 202865-65-4 C₇H₅BrFNO 
• 93777-26-5 5-bromo-2-fluorobenzaldehyde 
• 1404480-10-9 (E,Z)-5-bromo-2-fluoro-N-hydroxybenzimidoyl chloride 
• 74-89-5 methylamine 

Relevant articles and documents

COMBINATION OF KINASE INHIBITORS AND USES THEREOF

The present invention provides for a method for treating a disease condition associated with PI3-kinase a and/or mTOR in a subject. In another aspect, the invention provides for a method for treating a disease condition associated with PI3-kinase a and/or mTOR in a subject. In yet another aspect, a method of inhibiting phosphorylation of both Akt (S473) and Akt (T308) in a cell is set forth. The present invention also provides a pharmaceutical kit effective for treating a disease condition associated with PI3 -kinase α and/or mTOR in a subject.

BENZOXAZOLE KINASE INHIBITORS AND METHODS OF USE

The present invention provides chemical entities or compounds and pharmaceutical compositions thereof that are capable of modulating certain protein kinases such as mTor, tyrosine kinases, and/or lipid kinases such as PI3 kinase. Also provided in the present invention are methods of using these compositions to modulate activities of one or more of these kinases, especially for therapeutic applications.