14045-37-5

Upstream product

• 14371-10-9 (E)-3-phenylpropenal 
• 107-91-5 cyanoacetic acid amide 
• 98-86-2 acetophenone 
• 25327-42-8 (E)-2-cyano-3-phenylbut-2-enamide 
• 104-55-2 3-phenyl-propenal 
• 65996-13-6 2-Cyano-5-dimethylamino-3-phenyl-penta-2,4-diensaeurenitril 
• 1131-80-2 (E)-3-(N,N-dimethylamino)-1-phenyl-2-propen-1-one 
• 31916-15-1 (4E)-2-cyano-5-(N,N-dimethylamino)-3-phenyl-2,4-pentadienamide 
• 162738-55-8 2-cyano-3-phenylbutyramide 
• 1188-33-6 N,N-dimethylformamide diethyl diacetal 
• 124571-67-1 2-(3-dimethylamino-1-phenyl-2-propenylidene)-1,3-propanedinitrile 

Downstream Products

• 14045-36-4 2-oxo-4-phenyl-1,2-dihydropyridine-3-carboxamide 
• 1426831-83-5 C₁₇H₁₉N₃O 
• 133609-29-7 2-oxo-4-phenyl-1,2-dihydropyridine-3-carboxylic acid 

Relevant academic research and scientific papers

Enaminones as building blocks in heterocyclic syntheses: Reinvestigating the product structures of enaminones with malononitrile. A novel route to 6-substituted-3-oxo-2,3-dihydropyridazine-4-carboxylic acids

The reported structures of reaction products of enaminones with malononitrile in ethanolic piperidine are revised. A novel route to 2,3-dihydropyridazine-4-carboxylic acids 4a-c via reactions of 2-cyano-5-(dimethylamino)-5-arylpenta-2,4-dienamides 8a-c wi

A one-step preparation of functionalized 3-cyano-2-pyridones

Reaction of various enones and enals with cyanoacetamide in DMSO-tBuOK under an oxygen atmosphere furnishes 3-cyanopyridones directly and in good yield.

Synthesis and Photophysical Properties of 3-Amino-4-arylpyridin-2(1 H)-ones

A method has been developed for the preparation of oxazolo-[5,4- b ]pyridin-2(1 H)-ones based on the Hoffmann reaction of 2-oxo-1,2-dihydropyridine-3-carboxamides. Hydrolysis of oxazolo[5,4- b ]pyridin-2(1 H)-ones and the Hoffmann reaction of 2-oxo-1,2-dihydropyridine-3-carboxamides yielded 3-aminopyridin-2(1 H)-ones, including 4-aryl substituted derivatives in the series, for which effective phosphors with a quantum yield of up to 0.78 were detected. Photophysical properties of 3-aminopyridin-2(1 H)-ones were studied by UV and luminescence spectroscopy methods, and the relationship between their structure and photophysical properties was revealed.

INHIBITORS OF THE PD-1/PD-L1 PROTEIN/PROTEIN INTERACTION

The present invention provides novel compounds of formula (I) that are useful as inhibitors of the PD-1/PD-L1 protein/protein interaction.

Ionic liquid catalyzed 4,6-disubstituted-3-cyano-2-pyridone synthesis under solvent-free conditions

A green protocol for the synthesis of 4,6-disubstituted-3-cyano-2-pyridones from cyanoacetamides and 1,3-dicarbonyl compounds or chalcones using guanidine based ionic liquid as catalyst has been developed. In solvent-free conditions at 30 °C, [TMG][Lac] (1,1,3,3-tetramethylguanidine lactate) was found to have the highest catalytic activity among the ionic liquids including [TMG][Ac] (1,1,3,3-tetramethylguanidine acetate), [TMG][Pr] (1,1,3,3-tetramethylguanidine propionate), [TMG][n-Bu] (1,1,3,3-tetramethylguanidine n-butyrate) and [TMG][TFA] (1,1,3,3-tetramethylguanidine trifluoroacetate). The catalyst was recovered and recycled several times without significant loss of catalytic activity. Graphical Abstract: [Figure not available: see fulltext.]

1-Substituted 3-Dimethylaminoprop-2-en-1-ones as Building Blocks in Heterocyclic Synthesis: Routes to 6-Aryl and 6-Heteroaryl-2H-pyran-2-ones and 6- and 4-Aryl-pyridin-2(1H)-ones

Several new 6-substituted-3-acylamino-2H-pyran-2-ones 6 a-j are prepared from the reaction of the enaminones 4 a-f with N-acyl- and N-benzoyl-glycines. The enaminones 4 a-c react with malononitrile in ethanol solution and in presence of a base to yield th

Nonpeptidic inhibitors of human leukocyte elastase. 2. Design, synthesis, and in vitro activity of a series of 3-amino-6-arylopyridin-2-one trifluoromethyl ketones

A series of potent nonpeptidic inhibitors of the enzyme human leukocyte elastase (HLE) is reported. These inhibitors contain a 3-amino-2-pyridone ring as a central template in which the pyridone carbonyl and 3-position NH group are thought to form important hydrogen bonding interactions with the Val-216 residue of HLE. Substitution of the 6-position of the pyridone ring by various alkyl and aryl groups was found to afford increases in the in vitro potency of these inhibitors. A 6-position phenyl group, compound 10f, was found to result in a large increase in binding affinity, which was not obtained when the phenyl group was placed in either the 4- or 5-position of the molecule. Compound 10f was found to have good selectivity for HLE over other proteolytic enzymes, with the exception of bovine pancreatic chymotrypsin (BPC). Substitution of the 6-phenyl group in these molecules was found to decrease binding affinity for BPC without adversely affecting affinity for HLE.

A Simple Synthesis of Amphimedine

The marine alkaloid amphimedine has been synthesized by a short sequence of reactions commencing from the known indenopyridinedione (2).Reaction with 4-pyridillithium, followed by hydrazoic acid treatment, gave 5-(4-pyridyl)-3,6-phenanthrolin-4(3H)-one (1

A 'Biogenetic Like' Synthesis of Perloline, 6-(3,4-dimethoxyphenyl)-5-hydroxy-5,6-dihydrobenzonaphthyridin-4(3H)-one

9H-Indenopyridine-1(2H),9-dione, prepared by a new efficient route, reacts with 3,4-dimethoxyphenyllithium to form the keto alcohol (7), which rearranges with hydrazoic acid to form 5-(3,4-dimethoxyphenyl)benznaphthyridin-4(3H)-one.The N-oxide photolyses smoothly to yield dehydroperloline as the sole product.

A Siple and Efficient Synthesis of 3-Cyano-4-phenyl-2-pyridone

A preparatively useful method for the synthesis of 3-cyano-4-phenyl-2-pyridone (I) is described.Reaction of 2-cyano-3-methylcinnamamide (VII) with N,N-dimethylformamide dimethyl acetal affords the corresponding dimethylaminomethylidene amide VIII which in