19194-52-6

Usage

Uses

Used in Pharmaceutical Synthesis:
2,3-dihydro-3,3-diMethyl-1H-Isoindol-1-one is used as a key intermediate in the pharmaceutical industry for the synthesis of various drugs. Its unique chemical structure allows it to be a versatile building block, contributing to the development of new and innovative medications.
Used in Organic Chemistry:
In the field of organic chemistry, 2,3-dihydro-3,3-diMethyl-1H-Isoindol-1-one serves as a valuable reagent. It is utilized in various chemical reactions to facilitate the synthesis of complex organic compounds, enhancing the efficiency and effectiveness of these processes.
Used in Agrochemical Production:
2,3-dihydro-3,3-diMethyl-1H-Isoindol-1-one is also employed in the agrochemical industry, where it is used as a precursor in the production of various agrochemicals. Its role in this sector is crucial for the development of effective and safe products for agricultural applications.
Used in Industrial Applications:
Due to its stability and low toxicity, 2,3-dihydro-3,3-diMethyl-1H-Isoindol-1-one is suitable for use in a range of industrial applications. Its properties make it a preferred choice for various manufacturing processes, ensuring the production of high-quality and safe products.

Upstream product

• 184906-32-9 3,3-Dimethyl-5-(1-phenyl-1H-tetrazol-5-yloxy)-2,3dihydroisoindol-1-one 
• 17653-94-0 α-methyl-α-(3-methoxyphenyl)proprionic acid 
• 17653-93-9 2-(3'-Methoxyphenyl)-2-methylpropionitrile 
• 184906-31-8 5-Hydroxy-3,3-dimethyl-2,3-dihydroisoindol-1-one 
• 109138-26-3 1-(1-Isocyanato-1-methylethyl)-3-methoxybenzene 
• 184906-29-4 5-methoxy-3,3-dimethylisoindolin-1-one 
• 854694-37-4 3,3-dimethyl-isoindolin-1-one-imine 
• 585-32-0 2-phenyl-2-propylamine 
• 1404616-63-2 N-(1-methyl-1-phenylethyl)picolinamide 
• 1972-28-7 diethylazodicarboxylate 
• 3839-22-3 2-cyanobenzoic acid 
• 917-54-4 methyllithium 
• 53881-34-8 2-isopropylbenzoic acid chloride 
• 2438-04-2 2-isopropylbenzoic acid 

Relevant academic research and scientific papers

Synthesis of Lactams via Ir-Catalyzed C-H Amidation Involving Ir-Nitrene Intermediates

x-membered lactams were synthesized via either an amidation of sp3 C-H bonds or an electrophilic substitution of arenes via Ir-nitrene intermediates. With the employment of a readily available iridium catalyst in dichloromethane or hexafluoro-2-propanol, a wide range of lactams were synthesized in good to excellent yields with high selectivity.

MONOCYCLIC COMPOUNDS USEFUL AS GPR120 MODULATORS

Provided herein are compounds, compositions including them, and methods of modulating GPR120 activity and treating diseases mediated by GPR120 by administering such compounds and compositions.

Selective formation of γ-lactams via C-H amidation enabled by tailored iridium catalysts

Intramolecular insertion of met al nitrenes into carbon-hydrogen bonds to form γ-lactam rings has traditionally been hindered by competing isocyanate formation. We report the application of theory and mechanism studies to optimize a class of pentamethylcyclopentadienyl iridium(III) catalysts for suppression of this competing pathway. Modulation of the stereoelectronic properties of the auxiliary bidentate ligands to be more electron-donating was suggested by density functional theory calculations to lower the C-H insertion barrier favoring the desired reaction. These catalysts transform a wide range of 1,4,2-dioxazol-5-ones, carbonylnitrene precursors easily accessible from carboxylic acids, into the corresponding γ-lactams via sp3 and sp2 C-H amidation with exceptional selectivity. The power of this method was further demonstrated by the successful late-stage functionalization of amino acid derivatives and other bioactive molecules.

Traceless Directing Group Assisted Cobalt-Catalyzed C?H Carbonylation of Benzylamines

The first example of cobalt-catalyzed C(sp2)?H carbonylation of benzylamines using a traceless directing group is reported, which was successfully applied to the synthesis of N?unprotected iso-indolinones through direct C?H/N?H bonds activation. This protocol tolerates a variety of functional groups and provides a facile and efficient method for the formal synthesis of (+)-garenoxacin. (Figure presented.).

Transition-metal-free synthesis of phenanthridinones from biaryl-2-oxamic acid under radical conditions

Na2S2O8-promoted decarboxylative cyclization of biaryl-2-oxamic acid for phenanthridinones has been developed. This work illustrates the first example of intramolecular decarboxylative amidation of unactivated arene under transition-metal-free conditions. Additionally, this approach provides an efficient and economical method to access biologically interesting phenanthridinones, an important structure motif in many natural products. (Chemical Equation Presented).

Cyclic nitrones

The present invention is directed to novel cyclic nitrones and their use in the prevention of oxidation tissue damage by free radicals, their use in the treatment of a number of disease states in which radicals either damage or destroy tissues via oxidation, and pharmaceutical compositions containing these cyclic nitrones.

Design, synthesis, and in vitro evaluation of cyclic nitrones as free radical traps for the treatment of stroke

Analogs of the cyclic nitrone free radical trap 1 (3,3-dimethyl-3,4- dihydroisoquinoline N-oxide, a cyclic analog of phenyl-tert-butylnitrone (PBN)) were prepared in which (1) the fused phenyl ring was replaced with a naphthalene ring, an electron rich heterocycle, or a dimethylphenol, (2) the nitrone-containing ring comprised five, six, or seven atoms, and (3) the gem- dimethyl group was replaced with spirocyclic groups. The most active antioxidant, which bears a dimethylphenol fused to a 7-membered ring nitrone (compound 6h), inhibited lipid peroxidation in vitro with an IC50 of 22 μM, a 75-fold improvement over that of 1. The previously observed correlation between lipophilicity and activity vs lipid peroxidation in vitro has been further substantiated and refined by this study. Moreover, certain classes of compounds (namely, dimethylphenols 6g, h and furan 6j) have now been found which are considerably more active in vitro than expected on the basis of their log k'(w) values.