140630-38-2Relevant academic research and scientific papers
Dynamic kinetic resolution of β-azido alcohols. An efficient route to chiral aziridines and β-amino alcohols
Pamies,Baeckvall
, p. 4022 - 4025 (2001)
Enzymatic resolution of β-azido alcohols in combination with ruthenium-catalyzed alcohol isomerization led to a successful dynamic kinetic resolution. A variety of racemic β-azido alcohols were efficiently transformed to the corresponding enantiomerically pure acetates (ee up to 99% and conversion up to 98%). The synthetic utility of this procedure has been illustrated by the practical synthesis of (S)-propanolol I and (R)-β-azido-α-(4-methoxyphenyl)ethanol ((R)-1c), a direct precursor of denopamine II.
Lipase-catalyzed kinetic resolution of the racemic mixtures of 1- aryloxy-3-nitrato-and-1-aryloxy-3-azido-2-propanols
Pchelka, Beata,Radomska, Justyna,Plenkiewicz, Jan
, p. 4355 - 4364 (2007/10/03)
The racemic mixtures of 1-aryloxy-3-nitrato-2-propanols and 1-aryloxy- 3-azido-2-propanols were resolved with moderate selectivity by the lipase- mediated acylation with vinyl acetate. The effects of the nature, position, and spatial requirements of the p
Enzyme Assisted Preparation of Enantiomerically Pure β-Adrenergic Blockers II. Building Blocks of High Optical Purity and their Synthetic Conversion
Ader, Ulrich,Schneider, Manfred P.
, p. 205 - 208 (2007/10/02)
Based on previous screening results a series of potential building blocks 2-4 for β-adrenergic blockers were prepared both by enzymatic hydrolysis and acyltransfer and further transformed into the corresponding oxiranes and aminoalcohols of defined absolu
