14064-21-2

Usage

Uses

Used in Chemical Synthesis:
2-FURALDEHYDE DIMETHYLHYDRAZONE is used as a synthetic intermediate for the preparation of various chemical compounds, such as furyl-1,4-quinone and hydroquinones. It is particularly useful in the reaction with benzoand naphthoquinones to produce dimethylaminohydrazonofurylquinones.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-FURALDEHYDE DIMETHYLHYDRAZONE is used as a key component in the synthesis of certain drugs, taking advantage of its reactivity with other molecules to create new therapeutic agents.
Used in Research and Development:
2-FURALDEHYDE DIMETHYLHYDRAZONE is also utilized in research and development settings, where its chemical properties are explored for potential applications in the creation of new materials, catalysts, or other advanced chemical products.
Used in Analytical Chemistry:
In analytical chemistry, 2-FURALDEHYDE DIMETHYLHYDRAZONE can be employed as a reagent for the detection and identification of specific compounds, leveraging its unique chemical interactions to provide insights into the structure and composition of various substances.

InChI:InChI=1/C7H10N2O/c1-9(2)8-6-7-4-3-5-10-7/h3-6H,1-2H3/b8-6+

Upstream product

• 98-01-1 furfural 
• 57-14-7 N,N-Dimethylhydrazine 
• 540-73-8 1,2-Dimethylhydrazine 

Downstream Products

• 1016168-15-2 C₁₄H₁₂N₂O₄ 
• 1016168-14-1 3-acetyl-2-[5-(N,N-dimethylhydrazono)fur-2-yl]-1,4-benzoquinone 
• 1016168-13-0 C₁₅H₁₆N₂O₄ 
• 490-78-8 2,5-Dihydroxyacetophenone 
• 1016168-12-9 2-[5-(N,N-dimethylhydrazono)fur-2-yl]-5-methoxy-1,4-benzoquinone 
• 303095-04-7 1-{5-[(dimethylhydrazono)methyl]furan-2-yl}-2-hydroxy-2-phenylethanone 
• 617-89-0 furan-2-ylmethanamine 
• 1075-70-3 benzaldehyde N,N-dimethylhydrazone 
• 92011-72-8 3-((2,2-dimethylhydrazono)methyl)phthalonitrile 
• 1314779-69-5 [2-(dimethylamino)phenyl](furan-2-yl)methanone 

Relevant academic research and scientific papers

Polyoxometalate-Driven Ease Conversion of Valuable Furfural to trans- N, N-4,5-Diaminocyclopenten-2-ones

We investigated the catalytic efficacy of silicotungstic acid (H4SiW12O40) polyoxometalate (POM) toward the reaction between furfural and amines that selectively yields trans-N,N-4,5-substituted-diaminocyclopenten-2-ones (trans-DACPs). H4SiW12O40 facilita

THERAPEUTIC COMPOSITION OF CURE-PRO COMPOUNDS FOR TARGETED DEGRADATION OF BET DOMAIN PROTEINS, AND METHODS OF MAKING AND USAGE

The present application is directed to a therapeutic composition, comprising two precursor compounds (monomers) that are suitable for assembly via two or more reversible covalent bonds. The monomers are polyfunctionalized molecules comprising a bioorthogo

THERAPEUTIC CURE-PRO COMPOUNDS FOR TARGETED DEGRADATION OF BET DOMAIN PROTEINS, AND METHODS OF MAKING AND USING THEM

The present application is directed to a therapeutically useful compound, comprised of two monomers that are linked to each other through two or more reversible covalent bonds. Each monomer is a polyfunctionalized molecule comprising a bioorthogonal linker element and ligand or pharmacophore, wherein the linker and ligand/pharmacophore are covalently coupled to each other either directly or through an optional connector moiety.

AROMATIC COMPOUNDS FROM FURANICS

Described are methods for preparing phenols, benzene carboxylic acids, esters and anhydrides thereof from furanic compounds by reaction with a dienophile, wherein the furanic compounds are reacted with a hydrazine and/or oxime and then reacted with a dienophile.

Chemical cascades in water for the synthesis of functionalized aromatics from furfurals

One-pot synthetic routes from furfurals to polysubstituted aromatic compounds have been developed in water, without the need for any organic solvents. The reaction proceeds via an uncatalysed, one-pot reaction cascade through formation of a hydrazone derivative, in situ cycloaddition with a dienophile, then aromatisation. A range of substituted phthalimides can be accessed with complete control over the substitution pattern. The reaction was also extended to other dienophiles and the diene 2-furylacrolein. The phthalimide products were further elaborated to produce a variety of polysubstituted benzenes including pharmaceutically relevant compounds.

Synthesis of o -(dimethylamino)aryl ketones, acridones, acridinium salts, and 1 H -indazoles by the reaction of hydrazones and arynes

A novel, efficient route to biologically and pharmaceutically important o-(dimethylamino)aryl ketones, acridones, acridinium salts, and 1H-indazoles has been developed starting from readily available hydrazones of aldehydes and o-(trimethylsilyl)aryl triflates. The reaction proceeds through arynes under mild conditions, tolerates a wide range of functional groups, and provides the final products in good to excellent yields.

Synthesis of o -(dimethylamino)aryl ketones and acridones by the reaction of 1,1-dialkylhydrazones and arynes

A novel, efficient route to biologically and pharmaceutically important o-(dimethylamino)aryl ketones and acridones has been developed starting from readily available 1,1-dimethylhydrazones of aldehydes and o-(trimethylsilyl)aryl triflates. The reaction proceeds under mild conditions, tolerates a wide range of functional groups, and provides the final products in good to excellent yields.

From aldehydes to nitriles, a general and high yielding transformation using HOF·CH3CN complex

N,N-Dimethylhydrazones of aldehydes undergo a rapid oxidative cleavage to form nitriles in very high yields on reaction with HOF·CH3CN under mild conditions. The reaction is chemoselective and proceeds rapidly without racemization. The nitriles were resistant to further oxidation, even when a large excess of the reagent was employed.

A novel, one-pot synthesis of α-C-cyanohydrazines in the presence of lithium perchlorate/diethylether solution (5.0 M)

Condensation of N,N-dimethylhydrazine, an aldehyde in lithium perchlorate/diethylether solution (5.0 M) gave N,N-dimethylhydrazone, which were treated with trimethylsilylcyanide to afford α-C-cyanohydrazine. These compounds are important precursors of nitrogen-substituted reagents.

Furan-2-carbaldehyde Dimethylhydrazones in Diels-Alder Cycloadditions

Furan-2-carbaldehyde dimethylhydrazone and maleic anhydride and N-substituted maleimides and fumaronitrile in chloroform at room temperature readily formed nonisolable 1:1 cycloadducts which spontaneously lost water, giving 1,2,3-trisubstituted benzenes i