140696-23-7

Upstream product

• 129029-61-4 2-hydroxy-4-phenylbut-3-enoic acid 
• 866251-33-4 (+/-)-2-acetoxy-4-phenyl-3-butenoic acid 
• 866251-36-7 (S)-2-acetoxy-4-phenyl-3-butenoic acid 
• 140653-89-0 (E)-benzylideneglyoxylic acid potassium salt 
• 3483-12-3 diothiothreitol 
• 1914-59-6 (E)-2-oxo-4-phenyl-3-butenoic acid 
• 14371-10-9 (E)-3-phenylpropenal 

Downstream Products

• 99058-09-0 (2R,3S,4R)-3,4-dibromo-2-hydroxy-4-phenyl-butyric acid 
• 115016-95-0 (S)-2-hydroxy-4-phenylbutanoic acid 
• 129029-61-4 2-hydroxy-4-phenylbut-3-enoic acid 
• 140632-55-9 (R)-(E)-2-hydroxy-4-phenyl-3-butenoic acid 
• 29678-81-7 (R)-2-hydroxy4-phenylbutanoic acid 

Relevant academic research and scientific papers

Direct asymmetric hydrogenation of 2-oxo-4-arylbut-3-enoic acids

A challenging direct asymmetric hydrogenation of (E)-2-oxo-4-arylbut-3- enoic acids to give 2-hydroxy-4-arylbutanoic acids (85.4-91.8% ee) was achieved with a Ru catalyst based on SunPhos as the chiral ligand. Further investigation of the reaction revealed that partial isomerization of 2-hydroxy-4-arylbutenoic acids was involved in the hydrogenation process. Employing the reaction conditions to the hydrogenation of 2-oxo-4-phenylbutanoic acid resulted in better enantioselectivity (91.8% ee) and efficiency (TON = 2000, TOF = 200 h-1), which offers a useful method for the synthesis of a common intermediate for ACE inhibitors.

Chemo-enzymatic synthesis of (R)-and (S)-2-hydroxy-4-phenylbutanoic acid via enantio-complementary deracemization of (±)-2-hydroxy-4-phenyl-3- butenoic acid using a racemase-lipase two-enzyme system

Deracemization of (±)-2-hydroxy-4-phenylbut-3-enoic acid was accomplished by lipase-catalyzed kinetic resolution coupled to mandelate racemase-mediated racemization of the non-reacting substrate enantiomer. Stepwise cyclic repetition of this sequence led

Synthesis of homochiral 2-hydroxy acids

A process for the production of a homochiral 2-hydroxy carboxylic acid or salt thereof corresponding to general formula (I), wherein R represents one of formulae (II), (III), (IV), (V), wherein R' represents straight- or branched-chain alkyl or phenyl opt

ENANTIOSELECTIVE REDUCTION OF β,χ-UNSATURATED α-kETO ACIDS USING BACILLUS STEAROTHERMOPHILUS LACTATE DEHYDROGENASE: A NEW ROUTE TO FUNCTIONALISED ALLYLIC ALCOHOLS

The enantioselective reduction of α-keto acids, catalysed by lactate dehydrogenase, has been extended to β,χ-unsaturated substrates, providing functionalised allylic alcohols in high optical purity.