115016-95-0

Basic information

• Product Name: (S)-2-Hydroxy-4-phenylbutyric acid
• Synonyms: 2-(S)-HYDROXY-4-PHENYL-BUTYRIC ACID;(S)-2-HYDROXY-4-PHENYLBUTYRIC ACID;(S)-2-Hydroxy-4-phenylbutanoic acid;(S)-4-Phenyl-2-hydroxybutyric acid;Benzenebutanoic acid, a-hydroxy-, (aS)-;(S)-2-Hydroxy-4-phenylbutyric Acid
• CAS NO: 115016-95-0
• Molecular Formula: C₁₀H₁₂O₃
• Molecular Weight: 180.2
• Product Categories: Heterocyclic Compounds;Aromatics Compounds;Aromatics;Chiral Reagents;Intermediates
• Mol File: 115016-95-0.mol
• Article Data: 28

Chemical Properties

• Melting Point: 110-112°C
• Boiling Point: 356.9 °C at 760 mmHg
• Flash Point: 183.9 °C
• Appearance: White solid
• Density: 1.219 g/cm³
• Vapor Pressure: 1.03E-05mmHg at 25°C
• Refractive Index: 1.564
• Storage Temp.: -20?C Freezer
• Solubility: Chloroform (Slightly), Ethanol (Slightly), Ethyl Acetate (Slightly), Methanol (S
• PKA: 3.79±0.10(Predicted)
• CAS DataBase Reference: (S)-2-Hydroxy-4-phenylbutyric acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-Hydroxy-4-phenylbutyric acid(115016-95-0)
• EPA Substance Registry System: (S)-2-Hydroxy-4-phenylbutyric acid(115016-95-0)

Safety Data

• Hazardous Substances Data: 115016-95-0(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

(S)-2-Hydroxy-4-phenylbutyric acid is used in the preparation of benzothiophenes, benzofurans, and indoles useful in the treatment of insulin resistance and hyperglycemia.

InChI:InChI=1/C10H12O3/c11-9(10(12)13)7-6-8-4-2-1-3-5-8/h1-5,9,11H,6-7H2,(H,12,13)/t9-/m0/s1

Upstream product

• 710-11-2 2-oxo-4-phenylbutyric acid 
• 64-17-5 ethanol 
• 85290-51-3 (S)-1-nitro-4-phenyl-2-butanol 
• 146912-63-2 (S)-2-hydroxy-4-oxo-4-phenylbutanoic acid 
• 93921-85-8 ethyl 2-hydroxy-4-phenylbutanoate 
• 140696-23-7 (S)-2-hydroxy-4-phenyl-3-butenoic acid 
• 90239-50-2 C₁₄H₁₇NO₂ 
• 100-52-7 benzaldehyde 
• 1914-59-6 (E)-2-oxo-4-phenyl-3-butenoic acid 
• 1190946-81-6 (E)-N-(tert-butyl)-2-oxo-4-phenylbut-3-enamide 
• 4263-93-8 2-hydroxy-4-phenylbutanoic acid 
• 121054-03-3 2-hydroxy-4-phenylbutanenitrile 
• 103-63-9 1-phenyl-2-bromoethane 
• 64920-29-2 2-oxo-4-phenylbutanoic acid ethyl ester 

Downstream Products

• 129990-77-8 (2S)-2-Hydroxy-4-phenylbutyric acid methyl ester 
• 111496-88-9 (S)-1-{(S)-2-[Hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-4-phenyl-butyryl}-pyrrolidine-2-carboxylic acid benzyl ester 
• 710-11-2 2-oxo-4-phenylbutyric acid 
• 125639-64-7 (S)-ethyl 2-hydroxy-4-phenylbutyrate 
• 124988-64-3 (S)-4-phenyl-1,2-butanediol 
• 587-63-3 7,8-dihydrokawain 
• 913258-21-6 (4S)-4-(2-phenylethyl)-1,3,2-dioxathiolane 2-oxide 
• 90940-54-8 (αR)-α-amino-benzenebutanoic acid ethyl ester hydrochloride 
• 129277-07-2 ethyl (S)-2-methanesulfonyloxy-4-phenylbutanoate 
• 371255-35-5 ethyl (R)-2-azido-4-phenylbutanoate 
• 90315-82-5 ethyl (R)-2-hydroxy-4-phenylbutyrate 
• 870290-64-5 (3R,4S)-3-(trichloromethylcarbonylamino)-4-(methoxymethoxy)-6-phenylhexa-1-ene 
• 870290-61-2 2,2,2-Trichloro-acetimidic acid (E)-(S)-4-methoxymethoxy-6-phenyl-hex-2-enyl ester 
• 870290-54-3 ethyl (2E,4S)-4-methoxymethoxy-6-phenylhex-2-enoate 

Relevant articles and documents

Chirality switching in the enantioseparation of 2-hydroxy-4-phenylbutyric acid: Role of solvents in selective crystallization of the diastereomeric salt

Chirality switching was induced by solvents in the enantioseparation of 2-hydroxy-4-phenylbutyric acid (HPBA) via diastereomeric salt formation with an enantiopure aminoalcohol. The (S)-salt was crystallized from butanol solutions and the (R)-salt was obt

Asymmetric hydrogenation method of alpha-ketone amide compound

The invention belongs to the field of asymmetric catalysis, and discloses an asymmetric hydrogenation method of an alpha-ketone amide compound. The asymmetric hydrogenation method comprises the following steps that under the existence of a catalyst, alkali and a solvent, an alpha-ketone-beta-alkene amide compound is subjected to reduction in the hydrogen atmosphere, and an alpha-hydroxyl-beta alkene amide compound is obtained; and the catalyst is obtained through complexing of metal iridium salt and a chiral ligand, and the chiral ligand is selected from the following compounds: (the formulasare shown in the description). The asymmetric hydrogenation method is easy to operate, high in conversion rate and selectivity and low in cost, has the advantages of being high in atom economy and environmentally friendly, and has a very good industrialized application prospect.

Asymmetric hydrogenation reaction of alpha-ketoacids compound

The invention relates to the technical field of organic chemistry, especially to an asymmetric hydrogenation reaction of an alpha-ketoacids compound. The asymmetric hydrogenation reaction comprises a scheme shown in the description. In the scheme, R1 is phenyl, substituted phenyl, naphthyl, substituted naphthyl, C1-C6 alkyl, or aralkyl; a substituent group is C1-C6 alkyl, C1-C6 alkoxy, or halogen; and the number of the substituent group is 1-3. In the scheme, M is a chiral spiro-pyridylamino phosphine ligand iridium complex having a structure shown in the description. In the structure, R is hydrogen, 3-methyl, 4-tBu, or 6-methyl.