140706-33-8Relevant academic research and scientific papers
Ultrasound-assisted 3-component reaction in acetic acid alone: Catalyst/promoter/ligand free synthesis of bioactive pyrazolo[1,5-a]pyrimidines
Suresha, Namburi,Durgaraoa, Bodapati Veera,Ratnakar,Kolli, Sunder Kumar,Ashfaq, Mohd Ashraf,Rao, Mandava V. Basaveswara,Pal, Manojit
, p. 1176 - 1183 (2017/11/14)
Background: Acetic acid alone when employed as a solvent under ultrasound irradiation has been found to be effective for the three-component reaction involving ethyl-5- A mino-1H-pyrazole-4-carboxylate, aromatic aldehydes and terminal alkynes in the prese
Discovery, structure - Activity relationship, and biological evaluation of noninhibitory small molecule chaperones of glucocerebrosidase
Patnaik, Samarjit,Zheng, Wei,Choi, Jae H.,Motabar, Omid,Southall, Noel,Westbroek, Wendy,Lea, Wendy A.,Velayati, Arash,Goldin, Ehud,Sidransky, Ellen,Leister, William,Marugan, Juan J.
experimental part, p. 5734 - 5748 (2012/08/07)
A major challenge in the field of Gaucher disease has been the development of new therapeutic strategies including molecular chaperones. All previously described chaperones of glucocerebrosidase are enzyme inhibitors, which complicates their clinical development because their chaperone activity must be balanced against the functional inhibition of the enzyme. Using a novel high throughput screening methodology, we identified a chemical series that does not inhibit the enzyme but can still facilitate its translocation to the lysosome as measured by immunostaining of glucocerebrosidase in patient fibroblasts. These compounds provide the basis for the development of a novel approach toward small molecule treatment for patients with Gaucher disease. This article not subject to U.S. Copyright. Published 2012 by the American Chemical Society.
Synthesis and structure-activity relationship of tetrahydropyrazolopyrimidine derivatives - A novel structural class of potent calcium-sensing receptor antagonists
Yoshida, Masato,Mori, Akira,Inaba, Atsuhiro,Oka, Masahiro,Makino, Haruhiko,Yamaguchi, Masashi,Fujita, Hisashi,Kawamoto, Tomohiro,Goto, Mika,Kimura, Hiroyuki,Baba, Atsuo,Yasuma, Tsuneo
experimental part, p. 8501 - 8511 (2011/02/23)
A series of novel tetrahydropyrazolopyrimidine derivatives containing an adamantyl group were synthesized and evaluated as potential calcium-sensing receptor (CaSR) antagonists. After chemical modification of 9a, which was identified as a hit compound in
PREPARATION AND CHARACTERIZATION OF PYRAZOLOPYRIMIDINES
Maquestiau, A.,Taghret, H.,Eynde, J.-J. vanden
, p. 131 - 136 (2007/10/02)
1-Phenyl-1,3-butadione readily reacts with 3(5)-amino-1H-pyrazoles to yield mixtures of pyrazolopyrimidines which are identified by 1H nmr.Selective preparation of 5-methyl-7-phenylpyrazolopyrimidines can be achieved when 3-amino-1-phenyl-2-
