14080-34-3

Basic information

• Product Name: Pyrimidine, 2-methyl-5-nitro- (8CI,9CI)
• Synonyms: Pyrimidine, 2-methyl-5-nitro- (8CI,9CI);2-methyl-5-nitropyrimidine
• CAS NO: 14080-34-3
• Molecular Formula: C₅H₅N₃O₂
• Molecular Weight: 139.1121
• Product Categories: PYRIMIDINE
• Mol File: 14080-34-3.mol
• Article Data: 1

Chemical Properties

• Melting Point: 186-187 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 236.654ºC at 760 mmHg
• Flash Point: 96.925ºC
• Appearance: /
• Density: 1.338g/cm3
• Vapor Pressure: 0.072mmHg at 25°C
• Refractive Index: 1.564
• Storage Temp.: 2-8°C
• PKA: -1.30±0.22(Predicted)
• CAS DataBase Reference: Pyrimidine, 2-methyl-5-nitro- (8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrimidine, 2-methyl-5-nitro- (8CI,9CI)(14080-34-3)
• EPA Substance Registry System: Pyrimidine, 2-methyl-5-nitro- (8CI,9CI)(14080-34-3)

Safety Data

• Hazardous Substances Data: 14080-34-3(Hazardous Substances Data)

Usage

General Description

Pyrimidine, 2-methyl-5-nitro- (8CI,9CI) is a chemical compound that belongs to the pyrimidine family. It is characterized by the presence of a pyrimidine ring with a methyl group at the 2-position and a nitro group at the 5-position. Pyrimidine, 2-methyl-5-nitro- (8CI,9CI) is used in the synthesis of various pharmaceuticals and agrochemicals, and it also has potential applications in the field of materials science. The nitro group in this compound makes it a versatile building block for the synthesis of more complex molecules, and it is often used as a starting material in organic synthesis. However, it is important to handle this compound with care, as nitro compounds are known to be explosive and can be hazardous if mishandled.

InChI:InChI=1/C5H5N3O2/c1-4-6-2-5(3-7-4)8(9)10/h2-3H,1H3

Upstream product

• 124-42-5 acetamidine hydrochloride 
• 34461-00-2 nitromalondialdehyde sodium salt 
• 14080-32-1 5-nitropyrimidine 
• 110-89-4 piperidine 
• 143-37-3 acetamidine 

Downstream Products

• 15579-59-6 2-methyl-4-amino-5-nitropyrimidine 

Relevant articles and documents

Ring Transformations in Reactions of Heterocyclic Compounds with Nucleophiles. Conversion of 5-Nitropyrimidine into 2-Substituted 5-Nitropyrimidine and 2-Amino-5-nitropyridines by Amidines

The reaction of 5-nitropyrimidine (1) with benzamidine, pivalamidine, acetamidine, propionamidine, α-phenylacetamidine, O-methylisourea hydrochlorides, and cyanamide in ethanolic solution in the presence of triethylamine has been investigated.It was found that reaction of 1 with alkyl(aryl) amidines, having no active methylene groups attached to the amidine moiety (pivalamidine, benzamidine), exclusively formed the corresponding 2-substituted 5-nitropyrimidines in good yields.With acetamidine and propionamidine, in addition to the formation of the 2-substituted 5-nitropyrimidines, the formation of 2-amino-5-nitropyridines also was observed; with α-phenylacetamidine a 2-amino-5-nitropyridine derivative exclusively was obtained.The reaction of 1 with both O-methylisourea and cyanamide leads to 2-amino-5-nitropyrimidine.These reactions provide new examples of degenerate ring transformations of the pyrimidine ring system and of the ring transformation of pyrimidines into pyridines.