1408058-34-3

Upstream product

• 1393086-00-4 C₁₇H₂₂O₅ 
• 1408058-26-3 benzyl 2,3-O-isopentylidene-5-O-acetyl-α-D-lyxofuranoside 
• 1408058-27-4 benzyl 2,3-O-isopentylidene-5-O-trimethylsilyl-α-D-lyxofuranoside 
• 1393085-99-8 benzyl 2,3-O-isopentylidene-α-D-mannofuranoside 
• 1393085-98-7 benzyl 2,3:5,6-di-O-isopentylidene-α-D-mannofuranoside 
• 1408058-32-1 C₁₉H₂₉NO₅ 
• 1393085-97-6 2,3:5,6-di-O-isopentylidene-α-D-mannofuranose 
• 1408058-31-0 C₂₅H₄₃NO₅Si 
• 1408058-30-9 C₂₃H₃₉N₃O₄Si 
• 1408058-24-1 benzyl 2,3-O-isopentylidene-α-D-lyxofuranoside 
• 1408058-29-6 C₂₃H₄₀O₅Si 
• 1408058-28-5 C₁₇H₂₆O₅ 
• 3458-28-4 D-Mannose 

Downstream Products

• 1149345-89-0 ethyl (3R,4R,5R)-4-acetamido-3-(1-ethyl-propoxy)-5-hydroxy-cyclohex-1-ene-1-carboxylate 
• 1132659-99-4 (3R,4S,5R)-4-acetylamino-3-(1-ethyl-propoxy)-5-methanesulfonyloxy-cyclohex-1-enecarboxylic acid ethyl ester 
• 204255-06-1 oseltamivir 
• 196618-13-0 oseltamivir 
• 204255-11-8 oseltamivir phosphate 

Relevant academic research and scientific papers

A new and efficient asymmetric synthesis of oseltamivir phosphate(Tamiflu) from D-mannose

Oseltamivir phosphate (Tamiflu) was synthesized from D-mannose through a short and practical synthetic route. A unique feature of the route is that the bulky 3-pentyloxy group and adjacent acetamide of Tamiflu were introduced at an early stage of the synthesis by copper-catalyzed regioselective ringopening of the 2,3-pentylidene ketal of D-lyxofuranoside. The D-lyxofuranoside ethylphosphonate precursor was then cyclized via an intramolecular Horner-Wadsworth-Emmons reaction to furnish the Tamiflu skeleton.