1408238-41-4

Basic information

• Product Name: Dabigatran Impurity 9
• Synonyms: Dabigatran Impurity 9;1H-Benzimidazole-5-carboxylic acid, 2-[[[4-(aminoiminomethyl)phenyl]amino]methyl]-1-methyl-, ethyl ester;ethyl 2-(((4-carbamimidoylphenyl)amino)methyl)-1-methyl-1H-benzo[d]imidazole-5-carboxylate;Dabigatran Etexilate Impurity U
• CAS NO: 1408238-41-4
• Molecular Formula: C₁₉H₂₁N₅O₂
• Molecular Weight: 351.40234
• Mol File: 1408238-41-4.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Solubility: Methanol; Ethanol
• CAS DataBase Reference: Dabigatran Impurity 9(CAS DataBase Reference)
• NIST Chemistry Reference: Dabigatran Impurity 9(1408238-41-4)
• EPA Substance Registry System: Dabigatran Impurity 9(1408238-41-4)

Safety Data

• Hazardous Substances Data: 1408238-41-4(Hazardous Substances Data)

Usage

Uses

Des-(3-(Pyridin-2-ylamino)propanoate) Dabigatran Ethyl Ester is an intermediate in the synthesis of 2-[[[4-[(Z)-Amino[[(hexyloxy)carbonyl]imino]methyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazole-5-carboxylic Acid (A611088), a degradation product of Dabigatran (D100090). which is a drug that is a nonpeptide, direct thrombin inhibitor and an antithrombotic.

Upstream product

• 66315-23-9 ethyl 3-amino-4-(methylamino)benzoate 
• 1117893-66-9 ethyl 2-(((4-cyanophenyl)amino)methyl)-1-methyl-1H-benzo[d]imidazole-5-carboxylate 
• 42288-26-6 (4-cyanophenyl)glycine 
• 64-17-5 ethanol 
• 211915-84-3 3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester 

Downstream Products

• 1408238-36-7 ethyl 2-[[4-[(n-hexyloxycarbonyl)aminoiminomethyl]phenylamino]methyl]-1-methyl-1H-benzimidazole-5-carboxylate 

Relevant articles and documents

Preparation method of anticoagulant drug dabigatran etexilate and analogues thereof

The invention discloses a preparation method of an anticoagulant drug dabigatran etexilate and analogues thereof. The preparation method comprises the following steps: 3-[(3-amino-4-methylaminobenzoyl)pyridin-2-ylamino]propionic acid ethyl ester (DGM1) and isopropyl 2-(4-cyanophenylamino)acetate (DGM2) which are taken as reaction initial raw materials undergo a docking reaction under the action ofan alkali reagent and a condensing agent to prepare an intermediate DG1; the intermediate DG1 reacts in an alcohol solvent to produce imino ester, and acid catalysis and ammonia reaction are carriedout to prepare a formamidine compound; an intermediate DG2 reacts with n-hexyl chloroformate under the action of the alkali reagent to remove one molecule of water and form an amido bond in order to obtain dabigatran etexilate; and the dabigatran etexilate analogues DG-D1 to DG-D4 are prepared from the dabigatran etexilate and its intermediate DG2. The preparation method of the dabigatran etexilate and analogues thereof has the advantages of short and feasible synthesis route, simplicity in operation, high product yield is high, and suitableness for large-scale industrial production.