1408287-01-3Relevant academic research and scientific papers
Synthesis of the peptaibol framework of the anticancer agent culicinin D: Stereochemical assignment of the AHMOD moiety
Hung, Kuo-Yuan,Harris, Paul W. R.,Brimble, Margaret A.
supporting information, p. 5784 - 5787 (2013/01/15)
The postulated structure of the potent anticancer peptaibol culicinin D has been synthesized using Fmoc-based solid-phase peptide synthesis (SPPS). Comparison of the 1H NMR data for the reported structure of culicinin D with the data obtained for the two synthetic polypeptides epimeric at C-6 in the AHMOD unit established the C-6 stereochemistry of the AHMOD residue in the natural product to be (R).
