1408299-07-9

Upstream product

• 180692-68-6 (S)-5-(phenylmethoxy)-4-methylpentanal 
• 100-39-0 benzyl bromide 
• 1577-22-6 5-hexenoic acid 
• 3970-21-6 2-Methoxyethoxymethyl chloride 
• 1408299-04-6 (2S,5R,6S)-1-(benzyloxy)-2,6-dimethyldec-9-en-5-ol 
• 1408299-03-5 C₂₆H₃₆O₅S 
• 134916-00-0 (4S)-4-benzyl-3-(hex-5-enoyl)-1,3-oxazolidin-2-one 
• 5673-98-3 (S)-(-)-2-methyl-4-penten-1-ol 
• 887706-39-0 (S)-5-(benzyloxy)-4-methylpentan-1-ol 

Downstream Products

• 1408299-20-6 (3S,6R,7S,12S)-12-(benzyloxymethyl)-6-(2-mehtoxyethoxy)-3,7-dimethyloxacyclododec-10-en-2-one 
• 1408299-21-7 (3S,6R,7S,12S)-12-(benzyloxymethyl)-6-(2-mehtoxyethoxy) 

Relevant academic research and scientific papers

Asymmetric synthesis of a 12-membered macrolactone core and a 6-epi analogue of amphidinolide W from 4-pentenoic acid

A flexible and efficient asymmetric route to the synthesis of a 12-membered macrolactone core and a 6-epi analogue of amphidinolide W has been accomplished from commercially available 4-pentenoic acid. The successful generation of stereocenters was achieved by utilizing an Evans' chiral auxiliary-based alkylation and aldol reaction. Other key reactions such as a Julia-Kocienski olefination, Kita's macrolactonization, ring closing metathesis (RCM) reaction, and Yamaguchi's esterification were significant for the construction of the macrolactone cores.