14088-99-4

Usage

Uses

Used in Oncology:
Lonidamine is utilized as an antineoplastic agent for its capacity to interfere with the metabolic pathways of cancer cells, thereby inhibiting their growth and spread. It targets various enzymes and processes, which are pivotal for the sustenance and proliferation of malignant cells.
Used in Chemotherapy Enhancement:
In the realm of chemotherapy, lonidamine serves as a chemosensitizing agent, augmenting the effectiveness of chemotherapeutic drugs. It facilitates an increased uptake and retention of these drugs within cancer cells, thereby enhancing their cytotoxic impact and potentially overcoming drug resistance in cancer treatment.
Used in Pharmaceutical Research:
Lonidamine is also employed in pharmaceutical research as a subject for further investigation into its safety, efficacy, and potential side effects. This research is crucial for understanding the compound's full therapeutic potential and for developing strategies to mitigate any adverse effects, such as gastrointestinal disturbances and reproductive toxicity, which may currently restrict its clinical application.
While lonidamine has shown promise in the treatment of cancer, ongoing research is necessary to fully elucidate its mechanisms of action, optimize its therapeutic index, and establish its place in clinical oncology.

InChI:InChI=1/C9H9ClN2O/c10-7-1-3-8(4-2-7)12-6-5-11-9(12)13/h1-4H,5-6H2,(H,11,13)

Upstream product

• 497-25-6 dimethylenecyclourethane 
• 106-47-8 4-chloro-aniline 
• 120-93-4 imidazolidone 
• 637-87-6 1-Chloro-4-iodobenzene 
• 18523-47-2 3-azidopropanoic acid 
• 65536-39-2 N-(2-chloro-ethyl)-N'-(4-chloro-phenyl)-urea 

Downstream Products

• 68319-89-1 1-(4-chloro-phenyl)-3-nitroso-imidazolidin-2-one 
• 1169705-55-8 (3-{5-[3-(4-chloro-phenyl)-2-thioxo-imidazolidin-1-yl]-pentyloxy}-phenyl)-thiourea 
• 1169705-54-7 (3-{5-[3-(4-chloro-phenyl)-2-oxo-imidazolidin-1-yl]-pentyloxy}-phenyl)-thiourea 
• 519143-27-2 1-(4-chlorophenyl)-3-(5-[3-(4-methoxyphenoxy)propoxy]pentyl)-2-imidazolidinone 
• 1225208-10-5 C₁₇H₂₄ClN₃O 

Relevant academic research and scientific papers

Nucleophilic substitution of azide acting as a pseudo leaving group: One-step synthesis of various aza heterocycles

The reaction of 3-azidopropanoic acid with the carbodiimide-based coupling reagent DIC leads to a six-membered-ring intermediate acting as a versatile precursor to a diverse set of aza heterocycles, including mono-, bi-, and tricyclic compounds.

Mild, convenient and versatile Cu-mediated synthesis of N-aryl-2-imidazolidinones

A mild, general, convenient and practical methodology for the selective copper-mediated mono N-arylation of unprotected 2-imidazolidinone was developed. Strong electron-donating groups and free hydroxy and amino groups on the aryl iodide substrates were well tolerated. The use of n-butanol as the solvent for the copper-catalysed mono-arylation of 2-imidazolidinone is unprecedented.

Design and efficient synthesis of novel arylthiourea derivatives as potent hepatitis C virus inhibitors

A novel class of arylthiourea HCV inhibitors bearing various functionalities, such as cyclic urea, cyclic thiourea, urea, and thiourea, on the alkyl linker were designed and synthesized. Herein we report the synthesis and structure-activity relationships

IMIDAZOLIDINONE AND IMIDAZOLIDINETHIONE DERIVATIVES

Imidazolidinone and imidazolinethione compounds of formula (I): wherein R1, R2, R3, A1, A2, X, Y, Z, m, n, p, x, and y are defined herein. Also disclosed is a method of treating hepatitis C virus infe