65536-39-2

Basic information

• Product Name: 1-(2-chloroethyl)-3-(4-chlorophenyl)urea
• Synonyms: urea, N-(2-chloroethyl)-N'-(4-chlorophenyl)-
• CAS NO: 65536-39-2
• Molecular Formula: C₉H₁₀Cl₂N₂O
• Molecular Weight: 233.0945
• Mol File: 65536-39-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 327°C at 760 mmHg
• Flash Point: 151.5°C
• Density: 1.361g/cm³
• Vapor Pressure: 0.000209mmHg at 25°C
• Refractive Index: 1.599
• CAS DataBase Reference: 1-(2-chloroethyl)-3-(4-chlorophenyl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-chloroethyl)-3-(4-chlorophenyl)urea(65536-39-2)
• EPA Substance Registry System: 1-(2-chloroethyl)-3-(4-chlorophenyl)urea(65536-39-2)

Safety Data

• Hazardous Substances Data: 65536-39-2(Hazardous Substances Data)

Usage

General Description

1-(2-chloroethyl)-3-(4-chlorophenyl)urea is a chemical compound known for its herbicidal properties. It is commonly used as an herbicide to control weeds in agricultural and industrial settings. The compound is classified as a urea derivative and is characterized by its selective action on broadleaf weeds while being relatively safe for grasses. It works by inhibiting the growth of weeds and disrupting their biochemical processes, ultimately leading to their death. Due to its potent herbicidal properties, 1-(2-chloroethyl)-3-(4-chlorophenyl)urea is commonly utilized in weed control products and is considered to be an effective and efficient solution for weed management in various applications.

Upstream product

• 20729-41-3 acetaldehyde imine 
• 104-12-1 p-chlorphenylisocyanate 
• 1943-83-5 2-chloroethyl isothiocyanate 
• 106-47-8 4-chloro-aniline 

Downstream Products

• 1169705-55-8 (3-{5-[3-(4-chloro-phenyl)-2-thioxo-imidazolidin-1-yl]-pentyloxy}-phenyl)-thiourea 
• 1169705-54-7 (3-{5-[3-(4-chloro-phenyl)-2-oxo-imidazolidin-1-yl]-pentyloxy}-phenyl)-thiourea 
• 14088-99-4 1-(4-chlorophenyl)-2-imidazolidinone 
• 1848-67-5 2-(4-Chlor-anilino)-2-oxazolin 
• 13907-78-3 N-Nitroso-N-(2-chlor-aethyl)-N'-(4-chlor-phenyl)-harnstoff 
• 66671-20-3 N-(4-chloro-phenyl)-N'-(2-hydroxy-ethyl)-urea 

Relevant articles and documents

Design and efficient synthesis of novel arylthiourea derivatives as potent hepatitis C virus inhibitors

A novel class of arylthiourea HCV inhibitors bearing various functionalities, such as cyclic urea, cyclic thiourea, urea, and thiourea, on the alkyl linker were designed and synthesized. Herein we report the synthesis and structure-activity relationships

Antimitotic antitumor agents: Synthesis, structure-activity relationships, and biological characterization of N-aryl-N′-(2-chloroethyl)ureas as new selective alkylating agents

A series of N-aryl-N′-(2-chloroethyl)ureas (CEUs) and derivatives were synthesized and evaluated for antiproliferative activity against a wide panel of tumor cell lines. Systematic structure-activity relationship (SAR) studies indicated that: (i) a branched alkyl chain or a halogen at the 4-position of the phenyl ring or a fluorenyl/indanyl group, (ii) an exocyclic urea function, and (iii) a N′-2-chloroethyl moiety were required to ensure significant cytotoxicity. Biological experiments, such as immunofluorescence microscopy, confirmed that these promising compounds alter the cytoskeleton by inducing microtubule depolymerization via selective alkylation of β-tubulin. Subsequent evaluations demonstrated that potent CEUs were weak alkylators, were non-DNA-damaging agents, and did not interact with the thiol function of either glutathione or glutathione reductase. Therefore, CEUs are part of a new class of antimitotic agents. Finally, among the series of CEUs evaluated, compounds 12, 15, 16, and 27 were selected for further in vivo trials.

THE SYNTHESIS OF ANTINEOPLASTIC AGENTS. XXXII. N-NITROSOUREAS. I.

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