14091-60-2

Upstream product

• 506-93-4 guanidine nitrate 
• 55828-02-9 2-benzoylamino-2-cyanoacetic acid ethyl ester 
• 1004-75-7 2,5,6-triamino-3,4-dihydro-4-pyrimidinone 
• 98-88-4 benzoyl chloride 

Downstream Products

• 7780-10-1 2-amino-8-phenyl-1,7-dihydro-purin-6-one 
• 14173-37-6 2-amino-8-(4-nitro-phenyl)-1,7-dihydro-purin-6-one 
• 156006-89-2 6-chloro-8-phenyl-7⁽⁹⁾H-purin-2-ylamine 
• 1004-75-7 2,5,6-triamino-4-pyrimidinone 

Relevant academic research and scientific papers

NOVEL OXOISOQUINOLINE DERIVATIVE

The present invention provides with an oxoisoquinoline derivative represented by the formula (I) (in the formula, Q and R1 are as defined in the description) or a pharmaceutically acceptable salt thereof, which is useful as a Bruton's kinase inhibitor for treating cancer, B-cell lymphoma, chronic lymphocytic leukemia and the like.

Preparation method of substituted pyrimidone derivative

The invention provides a preparation method of a substituted pyrimidone derivative. The method comprises the steps of taking 2-amino-ethyl cyanoacetate as a raw material, performing three reactions of acylation, cyclization and hydrolysis, and finally obtaining 2,5,6-triamido-4-pyrimidone. Reaction conditions of the method are mild; the method is relatively low in cost, relatively high in yield and suitable for industrial mass production.