140927-07-7

Basic information

• Product Name: 2-Azabicyclo[2.2.1]hept-5-ene-2-carboxylic acid, phenylMethyl ester
• Synonyms: 2-Azabicyclo[2.2.1]hept-5-ene-2-carboxylic acid, phenylMethyl ester;benzyl 2-azabicyclo[2.2.1]hept-5-ene-2-carboxylate;(1R,4S)-benzyl 2-azabicyclo[2.2.1]hept-5-ene-2-carboxylate
• CAS NO: 140927-07-7
• Molecular Formula: C₁₄H₁₅NO₂
• Molecular Weight: 229.2744
• Mol File: 140927-07-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Azabicyclo[2.2.1]hept-5-ene-2-carboxylic acid, phenylMethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Azabicyclo[2.2.1]hept-5-ene-2-carboxylic acid, phenylMethyl ester(140927-07-7)
• EPA Substance Registry System: 2-Azabicyclo[2.2.1]hept-5-ene-2-carboxylic acid, phenylMethyl ester(140927-07-7)

Safety Data

• Hazardous Substances Data: 140927-07-7(Hazardous Substances Data)

Usage

General Description

2-Azabicyclo[2.2.1]hept-5-ene-2-carboxylic acid, phenylmethyl ester, also known as tropic acid phenylmethyl ester, is a chemical compound with the molecular formula C14H17NO2. It is a bicyclic heterocyclic compound and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Tropic acid phenylmethyl ester is also used as a building block in the production of various organic compounds. It is a white to off-white solid with a characteristic odor, and it is soluble in organic solvents. The compound is known for its potential therapeutic applications and is widely used in the pharmaceutical industry for its role in drug development.

Upstream product

• 49805-30-3 2-azabicyclo[2.2.1.]hept-5-en-3-one 
• 501-53-1 benzyl chloroformate 
• 50-00-0 formaldehyd 
• 542-92-7 cyclopenta-1,3-diene 
• 6671-85-8 2-azabicyclo[2.2.1]hept-5-ene 

Downstream Products

• 286946-66-5 benzyl 3-oxo-2,6-diazabicyclo[3.2.1]-octane-6-carboxylate 
• 286946-90-5 benzyl 5-(hydroxyimino)-2-azabicyclo[2.2.1]heptane-2-carboxylate 
• 1217190-38-9 (1R,4R,5S)-Benzyl 5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate 
• 1272321-75-1 benzyl 5-(tosyloxyimino)-2-azabicyclo[2.2.1]heptane-2-carboxylate 
• 140927-17-9 2,2-Diphenyl-propionic acid (1R,4R,5R)-2-methyl-2-aza-bicyclo[2.2.1]hept-5-yl ester 
• 140927-10-2 2,2-Diphenyl-propionic acid (1S,4S,5R)-2-methyl-2-aza-bicyclo[2.2.1]hept-5-yl ester 
• 140927-14-6 endo-2-(carbobenzyloxy)-2-azabicyclo<2.2.1>heptan-5-ol 
• 140927-13-5 2-(carbobenzyloxy)-2-azabicyclo<2.2.1>heptan-5-one 
• 223683-19-0 5-(6'-chloro-3'-pyridyl)-N-(benzyloxycarbonyl)-2-azabicyclo[2.2.1]hept-5-ene 
• 223683-25-8 6-(6'-chloro-3'-pyridyl)-N-(benzyloxycarbonyl)-2-azabicyclo[2.2.1]hept-6-ene 
• 179023-39-3 N-(benzyloxycarbonyl)-2-azabicyclo[2.2.1]heptan-6-one 
• 140927-13-5 benzyl 5-oxo-2-azabicyclo[2.2.1]heptane-2-carboxylate 
• 140927-08-8 2-(carbobenzyloxy)-5,6-epoxy-2-azabicyclo<2.2.1>heptane 
• 141017-63-2 exo-2-(carbobenzyloxy)-2-azabicyclo<2.2.1>heptan-6-ol 

Relevant articles and documents

Histamine H3 Inverse Agonists and Antagonists and Methods of Use Thereof

Provided herein are fused imidazolyl compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, including, e.g., neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as, e.g., histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical compositions containing the compounds and their methods of use are also provided herein.

Synthesis and Muscarinic Receptor Activity of Ester Derivatives of 2-Substituted 2-Azabicycloheptan-5-ol and -6-ol

Radioligand binding affinities of four new muscarinic antagonists and six potential muscarinic agonists which possess the 2-alkyl-2-azabicycloheptane ring system have been determined in rat heart, rat brain, and m1- or m3-tran