140927-07-7

Usage

Uses

Used in Pharmaceutical Industry:
2-Azabicyclo[2.2.1]hept-5-ene-2-carboxylic acid, phenylmethyl ester is used as an intermediate in the synthesis of various pharmaceuticals for its role in drug development. It contributes to the creation of new medications and the improvement of existing ones, enhancing their efficacy and safety.
Used in Agrochemical Synthesis:
In the agrochemical industry, 2-Azabicyclo[2.2.1]hept-5-ene-2-carboxylic acid, phenylmethyl ester is utilized as an intermediate in the production of various agrochemicals. Its involvement in the synthesis process helps develop more effective and safer products for agricultural applications.
Used in Organic Compound Production:
2-Azabicyclo[2.2.1]hept-5-ene-2-carboxylic acid, phenylmethyl ester also serves as a building block in the production of a wide range of organic compounds. Its versatility in chemical reactions allows for the creation of diverse organic molecules with various applications in different industries.

Upstream product

• 542-92-7 cyclopenta-1,3-diene 
• 50-00-0 formaldehyd 
• 501-53-1 benzyl chloroformate 
• 49805-30-3 2-azabicyclo[2.2.1.]hept-5-en-3-one 
• 6671-85-8 2-azabicyclo[2.2.1]hept-5-ene 

Downstream Products

• 140927-13-5 benzyl 5-oxo-2-azabicyclo[2.2.1]heptane-2-carboxylate 
• 179023-39-3 N-(benzyloxycarbonyl)-2-azabicyclo[2.2.1]heptan-6-one 
• 223683-25-8 6-(6'-chloro-3'-pyridyl)-N-(benzyloxycarbonyl)-2-azabicyclo[2.2.1]hept-6-ene 
• 223683-19-0 5-(6'-chloro-3'-pyridyl)-N-(benzyloxycarbonyl)-2-azabicyclo[2.2.1]hept-5-ene 
• 1272321-75-1 benzyl 5-(tosyloxyimino)-2-azabicyclo[2.2.1]heptane-2-carboxylate 
• 1217190-38-9 (1R,4R,5S)-Benzyl 5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate 
• 286946-90-5 benzyl 5-(hydroxyimino)-2-azabicyclo[2.2.1]heptane-2-carboxylate 
• 286946-66-5 benzyl 3-oxo-2,6-diazabicyclo[3.2.1]-octane-6-carboxylate 
• 140927-17-9 2,2-Diphenyl-propionic acid (1R,4R,5R)-2-methyl-2-aza-bicyclo[2.2.1]hept-5-yl ester 
• 140927-10-2 2,2-Diphenyl-propionic acid (1S,4S,5R)-2-methyl-2-aza-bicyclo[2.2.1]hept-5-yl ester 
• 140927-14-6 endo-2-(carbobenzyloxy)-2-azabicyclo<2.2.1>heptan-5-ol 
• 140927-13-5 2-(carbobenzyloxy)-2-azabicyclo<2.2.1>heptan-5-one 
• 140927-08-8 2-(carbobenzyloxy)-5,6-epoxy-2-azabicyclo<2.2.1>heptane 
• 141017-63-2 exo-2-(carbobenzyloxy)-2-azabicyclo<2.2.1>heptan-6-ol 

Relevant academic research and scientific papers

Histamine H3 Inverse Agonists and Antagonists and Methods of Use Thereof

Provided herein are fused imidazolyl compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, including, e.g., neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as, e.g., histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical compositions containing the compounds and their methods of use are also provided herein.

CYCLOALKANOPYRIDINE DERIVATIVE

Provided are cycloalkanopyridine derivatives of formula [I]: [wherein the symbols are the same as those stated in the description]. The compounds act as a nociceptin receptor antagonist, and are useful as medicines for diseases associated with a nociceptin receptor, for example, as a reliever against tolerance to a narcotic analgesic; a reliever against dependence on or addiction to a narcotic analgesic; an analgesic enhancer; an antiobesitic or appetite suppressor; a treating or prophylactic agent for cognitive impairment and dementia/amnesia; an agent for treating developmental cognitive abnormality; a remedy for schizophrenia; an agent for treating neurodegenerative diseases; an anti-depressant or treating agent for affective disorder; a treating or prophylactic agent for diabetes insipidus; a treating or prophylactic agent for polyuria; or a remedy for hypotension.

Synthesis and Muscarinic Receptor Activity of Ester Derivatives of 2-Substituted 2-Azabicycloheptan-5-ol and -6-ol

Radioligand binding affinities of four new muscarinic antagonists and six potential muscarinic agonists which possess the 2-alkyl-2-azabicycloheptane ring system have been determined in rat heart, rat brain, and m1- or m3-tran