140927-13-5

Basic information

• Product Name: benzyl 5-oxo-2aza-bicyclo[2.2.1]heptance-2-carboxylate
• Synonyms: benzyl 5-oxo-2aza-bicyclo[2.2.1]heptance-2-carboxylate;Benzyl 5-oxo-2-azabicyclo[2.2.1]heptane-2-carboxylate;2-Azabicyclo[2.2.1]heptane-2-carboxylic acid, 5-oxo-, phenylMethyl ester;5-Oxo-2-azabicyclo[2.2.1]heptane-2-carboxylic Acid Phenylmethyl Ester;(1R,4R)-benzyl 5-oxo-2-azabicyclo[2.2.1]heptane-2-carboxylate;5-Oxo-2-aza-bicyclo[2.2.1]heptane-2-carboxylic acid benzyl ester
• CAS NO: 140927-13-5
• Molecular Formula: C₁₄H₁₅NO₃
• Molecular Weight: 245.27
• Mol File: 140927-13-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 402.515oC at 760 mmHg
• Flash Point: 197.234oC
• Appearance: /
• Density: 1.284g/cm3
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.594
• Storage Temp.: 2-8°C
• PKA: -1.07±0.20(Predicted)
• CAS DataBase Reference: benzyl 5-oxo-2aza-bicyclo[2.2.1]heptance-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 5-oxo-2aza-bicyclo[2.2.1]heptance-2-carboxylate(140927-13-5)
• EPA Substance Registry System: benzyl 5-oxo-2aza-bicyclo[2.2.1]heptance-2-carboxylate(140927-13-5)

Safety Data

• Hazardous Substances Data: 140927-13-5(Hazardous Substances Data)

Usage

Uses

5-Oxo-2-azabicyclo[2.2.1]heptane-2-carboxylic Acid Phenylmethyl Ester is an intermediate in the synthesis of potent agonists of nicotinic acetylcholine receptors.

InChI:InChI=1/C14H15NO3/c16-13-7-12-6-11(13)8-15(12)14(17)18-9-10-4-2-1-3-5-10/h1-5,11-12H,6-9H2

Upstream product

• 1217190-38-9 (1R,4R,5S)-Benzyl 5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate 
• 542-92-7 cyclopenta-1,3-diene 
• 6671-85-8 2-azabicyclo[2.2.1]hept-5-ene 
• 140927-12-4 exo-2-(carbobenzyloxy)-2-azabicyclo<2.2.1>heptan-5-ol 
• 140927-07-7 2-(carbobenzyloxy)-2-azabicyclo<2.2.1>hept-5-ene 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 140927-17-9 2,2-Diphenyl-propionic acid (1R,4R,5R)-2-methyl-2-aza-bicyclo[2.2.1]hept-5-yl ester 
• 1272321-75-1 benzyl 5-(tosyloxyimino)-2-azabicyclo[2.2.1]heptane-2-carboxylate 
• 223683-19-0 5-(6'-chloro-3'-pyridyl)-N-(benzyloxycarbonyl)-2-azabicyclo[2.2.1]hept-5-ene 
• 286946-68-7 benzyl 2-(6-chloro-3-pyridinyl)-2,6-diazabicyclo[3.2.1]octane-6-carboxylate 
• 286946-98-3 tert-butyl 2,6-diazabicyclo[3.2.1]octane-2-carboxylate 
• 286946-67-6 benzyl 2,6-diazabicyclo[3.2.1]-octane-6-carboxylate 
• 286946-66-5 benzyl 3-oxo-2,6-diazabicyclo[3.2.1]-octane-6-carboxylate 
• 286946-90-5 benzyl 5-(hydroxyimino)-2-azabicyclo[2.2.1]heptane-2-carboxylate 
• 140927-14-6 endo-2-(carbobenzyloxy)-2-azabicyclo<2.2.1>heptan-5-ol 

Relevant articles and documents

Histamine H3 Inverse Agonists and Antagonists and Methods of Use Thereof

Provided herein are fused imidazolyl compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, including, e.g., neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as, e.g., histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical compositions containing the compounds and their methods of use are also provided herein.

Synthesis and Muscarinic Receptor Activity of Ester Derivatives of 2-Substituted 2-Azabicycloheptan-5-ol and -6-ol

Radioligand binding affinities of four new muscarinic antagonists and six potential muscarinic agonists which possess the 2-alkyl-2-azabicycloheptane ring system have been determined in rat heart, rat brain, and m1- or m3-tran