1409941-45-2Relevant academic research and scientific papers
Transannular O -heterocyclization: A useful tool for the total synthesis of Murisolin and 16,19- cis -Murisolin
Persich, Peter,Kerschbaumer, Julia,Helling, Sandra,Hildmann, Barbara,Wibbeling, Birgit,Haufe, Günter
supporting information, p. 5628 - 5631 (2013/01/15)
Transannular O-heterocyclization is applied as a key step in a total synthesis. This highly stereoselective and metal-free transformation introduces four stereocenters in one step. It was chosen to be the pivotal step in the synthesis of Murisolin and 16,19-cis-Murisolin, two annonaceous acetogenins. The efficiency of this synthesis is further illustrated by a stereodivergent late-stage separation of both synthetic routes.
