1410131-50-8

Upstream product

• 1622-32-8 2-Chloroethanesulfonyl chloride 
• 104-86-9 4-chlorobenzylamine 

Downstream Products

• 1410130-10-7 C₂₁H₂₄ClFN₂O₄S 
• 1410129-98-4 C₂₂H₂₇ClN₂O₄S 
• 1410130-92-5 3-(4-chlorobenzyl)-8-fluoro-6,10b-dihydro-1H-[1,2,4]thiadiazino[5,4-a]isoindol-4(3H)-one 2,2-dioxide 
• 1410131-17-7 3-(4-chlorobenzyl)-9-methyl-6,10b-dihydro-1H-[1,2,4]thiadiazino[5,4-a]isoindol-4(3H)-one 2,2-dioxide 
• 1410130-62-9 3-(4-chlorobenzyl)-3,4,6,10b-tetrahydro-1H-[1,2,4]thiadiazino[5,4-a]isoindole 2,2-dioxide 
• 1410130-96-9 3-(4-chlorobenzyl)-8-fluoro-3,4,6,10b-tetrahydro-1H-[1,2,4]thiadiazino[5,4-a]isoindole 2,2-dioxide 
• 1410131-22-4 3-(4-chlorobenzyl)-9-methyl-3,4,6,10b-tetrahydro-1H-[1,2,4]thiadiazino[5,4-a]isoindole 2,2-dioxide 
• 1410130-60-7 3-(4-chlorobenzyl)-6,10b-dihydro-1H-[1,2,4]thiadiazino[5,4-a]isoindol-4(3H)-one 2,2-dioxide 
• 1410129-83-7 C₂₁H₂₅ClN₂O₄S 
• 1508265-94-8 2-(4-chlorobenzyl)octahydro-1H-pyrido[2,1-d][1,2,5]thiadiazepin-1-one 3,3-dioxide 
• 1508266-10-1 (S)-2-(4-chlorobenzyl)-4-methyl-1,2,5-thiadiazepan-3-one 1,1-dioxide 

Relevant academic research and scientific papers

Rapid, scalable assembly of stereochemically rich, mono- and bicyclic acyl sultams

A one-pot, sequential protocol is reported that involves complementary ambiphile pairing (CAP) of a vinyl sulfonamide with a variety of unprotected amino acids via aza-Michael addition and subsequent intramolecular amidation. The method generates diverse, sp3-rich mono- and bicyclic acyl sultams in a highly scalable manner. Modular pairing of stereochemically rich building blocks allows quick access to all possible isomers. Extension to include one-pot, sequential 3-, 4-, and 5-multicomponent protocols is also discussed.