1410805-00-3Relevant articles and documents
A macrocyclic approach to tetracycline natural products. Investigation of transannular alkylations and Michael additions
Wzorek, Joseph S.,Kn?pfel, Thomas F.,Sapountzis, Ioannis,Evans, David A.
supporting information, p. 5840 - 5843 (2013/02/25)
A new approach to the tetracycline core structure is presented. The pivotal intermediate is identified as macrocycle III. The two interior bonds (C4a-C12a and C5a-C11a) are to be constructed through sequential transannular Michael additions (III-II) and compression-promoted transannular isoxazole alkylations from intermediate II.