1410805-08-1

Basic information

• Product Name: tert-butyl ((1S,5R)-5-(3-(benzyloxy)-2-ethynylphenyl)-1-(3-(benzyloxy)-4-((R)-1-((triethylsilyl)oxy)but-3-en-1-yl)isoxazol-5-yl)-2-hydroxy-4-oxo-5-((2-(trimethylsilyl)ethoxy)methoxy)hexyl)carbamate
• Synonyms: tert-butyl ((1S,5R)-5-(3-(benzyloxy)-2-ethynylphenyl)-1-(3-(benzyloxy)-4-((R)-1-((triethylsilyl)oxy)but-3-en-1-yl)isoxazol-5-yl)-2-hydroxy-4-oxo-5-((2-(trimethylsilyl)ethoxy)methoxy)hexyl)carbamate
• CAS NO: 1410805-08-1
• Molecular Weight: 941.322
• Mol File: 1410805-08-1.mol

Chemical Properties

• CAS DataBase Reference: tert-butyl ((1S,5R)-5-(3-(benzyloxy)-2-ethynylphenyl)-1-(3-(benzyloxy)-4-((R)-1-((triethylsilyl)oxy)but-3-en-1-yl)isoxazol-5-yl)-2-hydroxy-4-oxo-5-((2-(trimethylsilyl)ethoxy)methoxy)hexyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl ((1S,5R)-5-(3-(benzyloxy)-2-ethynylphenyl)-1-(3-(benzyloxy)-4-((R)-1-((triethylsilyl)oxy)but-3-en-1-yl)isoxazol-5-yl)-2-hydroxy-4-oxo-5-((2-(trimethylsilyl)ethoxy)methoxy)hexyl)carbamate(1410805-08-1)
• EPA Substance Registry System: tert-butyl ((1S,5R)-5-(3-(benzyloxy)-2-ethynylphenyl)-1-(3-(benzyloxy)-4-((R)-1-((triethylsilyl)oxy)but-3-en-1-yl)isoxazol-5-yl)-2-hydroxy-4-oxo-5-((2-(trimethylsilyl)ethoxy)methoxy)hexyl)carbamate(1410805-08-1)

Safety Data

• Hazardous Substances Data: 1410805-08-1(Hazardous Substances Data)

Upstream product

• 1410804-95-3 (R)-3-(3-(benzyloxy)-2-ethynylphenyl)-3-hydroxybutan-2-one 
• 76513-69-4 (2-trimethylethylsilylethoxy)methyl chloride 
• 863870-72-8 O-3-bromophenyl N,N-diethylcarbamate 
• 1410804-94-2 (2R,3S)-2-(3-(benzyloxy)-2-ethynylphenyl)butane-2,3-diol 
• 1410804-96-4 (R)-3-(3-(benzyloxy)-2-ethynylphenyl)-3-((2-(trimethylsilyl)ethoxy)methoxy)but-an-2-one 
• 1410804-93-1 ((2-(benzyloxy)-6-bromophenyl)ethynyl)trimethylsilane 
• 206002-17-7 2-(benzyloxy)-6-bromobenzaldehyde 
• 22532-61-2 2-bromo-6-hydroxybenzaldehyde 
• 1410805-06-9 tert-butyl ((R)-1-(3-(benzyloxy)-4-((R)-1-((triethylsilyl)oxy)but-3-en-1-yl)isoxazol-5-yl)-2-oxoethyl)carbamate 
• 1410804-98-6 (R)-3-(3-(benzyloxy)-2-ethynylphenyl)-1-bromo-3-((2-(trimethylsilyl)ethoxy)methoxy)-butan-2-one 
• 1410805-05-8 tert-butyl ((S)-1-(3-(benzyloxy)-4-((R)-1-((triethylsilyl)oxy)but-3-en-1-yl)isoxazol-5-yl)-2-hydroxyethyl)carbamate 
• 1410805-04-7 tert-butyl ((S)-1-(3-(benzyloxy)-4-((R)-1-((triethylsilyl)oxy)but-3-en-1-yl)isoxazol-5-yl)-2-((triethylsilyl)oxy)ethyl)carbamate 
• 1410805-03-6 tert-butyl ((S)-1-(3-(benzyloxy)-4-((R)-1-hydroxybut-3-en-1-yl)isoxazol-5-yl)-2-hydroxyethyl)carbamate 
• 1410805-02-5 (S)-tert-butyl 4-(3-(benzyloxy)-4-((R)-1-hydroxybut-3-en-1-yl)isoxazol-5-yl)-2,2-dimethyloxazolidine-3-carboxylate 

Relevant articles and documents

A macrocyclic approach to tetracycline natural products. Investigation of transannular alkylations and Michael additions

A new approach to the tetracycline core structure is presented. The pivotal intermediate is identified as macrocycle III. The two interior bonds (C4a-C12a and C5a-C11a) are to be constructed through sequential transannular Michael additions (III-II) and compression-promoted transannular isoxazole alkylations from intermediate II.