141102-07-0Relevant articles and documents
Synthesis and biological evaluation of novel indole derivatives containing sulfonamide scaffold as potential tubulin inhibitor
Man, Ruo-Jun,Tang, Dan-Jie,Lu, Xiao-Yuan,Duan, Yong-Tao,Tao, Xiang-Xiang,Yang, Meng-Ru,Wang, Le-Le,Wang, Bao-Zhong,Xu, Chen,Zhu, Hai-Liang
, p. 1759 - 1767 (2016/09/23)
Microtubule-targeted drugs play a critical role in various types of cancer therapy worldwide. In our study, a series of novel indole derivatives containing a sulfonamide scaffold were designed, synthesized and biologically evaluated as potential tubulin p
NOVEL INDOLE AND PYRROLOPYRIDINE AMIDES
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Page/Page column 64, (2012/09/11)
The present invention relates to indole and pyrrolopyridine amide derivatives of formula (I) wherein R1, R 2, R 3, U, V, W, X, Y, Z and ring A are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as orexin receptor antagonists.
Design, synthesis, and biological activity of potent and selective inhibitors of mast cell tryptase
Hopkins, Corey R.,Czekaj, Mark,Kaye, Steven S.,Gao, Zhongli,Pribish, James,Pauls, Henry,Liang, Guyan,Sides, Keith,Cramer, Dona,Cairns, Jennifer,Luo, Yongyi,Lim, Heng-Keang,Vaz, Roy,Rebello, Sam,Maignan, Sebastian,Dupuy, Alain,Mathieu, Magali,Levell, Julian
, p. 2734 - 2737 (2007/10/03)
A new series of novel mast cell tryptase inhibitors is reported, which features the use of an indole structure as the hydrophobic substituent on a m-benzylaminepiperidine template. The best members of this series display good in vitro activity and excellent selectivity against other serine proteases.