141109-90-2

Upstream product

• 400755-52-4 C₁₅H₁₀Cl₂O₃ 
• 491-38-3 1-benzopyran-4(4H)-one 
• 541-73-1 1,3-Dichlorobenzene 
• 118-93-4 o-hydroxyacetophenone 
• 874-42-0 2,4-dichlorobenzaldeyhde 
• 145626-26-2 3-(2,4-dichlorophenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one 
• 88701-85-3 (E)-3-(2,6-Dichloro-phenyl)-1-(2-hydroxy-phenyl)-propenone 
• 83-38-5 2,6-dichlorobenzaldehyde 

Relevant academic research and scientific papers

Water-mediated phosphorylative cyclodehydrogenation: An efficient preparation of flavones and flavanones

A new synthetic strategy utilizing POCl3-water for the conversion of 2′-hydroxychalcones to flavanones and flavones has been developed. The reagent efficiently promoted one-pot conversion of 2′-hydroxychalcones to flavones through flavanones involving cyclization and oxidative dehydrogenation. By changing the stoichiometery of the reagents, the reaction can be tuned to generate either flavanone or flavone. The developed protocol was found to be applicable for a variety of 2′-hydroxychalcones.

In vitro enzyme inhibition potentials and antioxidant activity of synthetic flavone derivatives

Free radicals are produced by an important chemical process known as oxidation that in turn initiates chain reactions to damage the cells and originate oxidative stress. Flavones have got special position in research field of natural and synthetic organic chemistry due to their biological capabilities as antioxidant. The antioxidants are known to possess extensive biological effects that include antiviral, antibacterial, anti-inflammatory, antithrombotic, and vasodilatory activities. The simple flavone (F1) and substituted flavone derivatives (F2-F5) have been synthesized from o-hydroxyacetophenone and benzaldehyde derivatives in good yield. The structures have been established by different spectroscopic techniques like 1H NMR, 13C NMR, IR, and elemental analysis. Antioxidant profile of these compounds was established using DPPH and H2O2 free radical scavenging assay. The findings showed that halogenated flavones showed more enzyme inhibitions and antioxidant activities than simple flavones and are potential candidates for the treatment of wide range of diseases.

Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor

Central neuromedin U 2 receptor (NMU2R) plays important roles in the regulation of food intake and body weight. Identification of NMU2R agonists may lead to the development of pharmaceutical agents to treat obesity. Based on the structure of rutin, a typi

Cyclization of 2'-hydroxychalcones to flavones using ammonium iodide as an iodine source - An eco-friendly approach

Ammonium iodide on exposure to air decomposes to ammonia and iodine. The in situ generated iodine was used for the cyclization of 2'-hydroxychalcones to the corresponding flavones under solvent-free conditions in good to excellent yields. This method could serve as an attractive alternative to the existing methods for synthesis of flavones and the use of toxic molecular iodine is avoided. Copyright

Palladium-catalyzed oxidative arylation of chromones via a double C-H activation: An expedient approach to flavones

A palladium-catalyzed oxidative arylation of chromones was examined. A regioselective 2-arylation of chromone was carried out via a double C-H activation process. The procedure provided an expedient approach for the preparation of flavone derivatives.

A facile synthesis of flavones catalysed by gallium(III) triflate

Ga(OTf)3 was explored as a novel catalyst for the cyclisation of 1-(2-hydroxyphenyl)-3-aryl-1,3-propanediones in nitromethane to flavones with excellent yields.