88701-85-3

Upstream product

• 118-93-4 o-hydroxyacetophenone 
• 83-38-5 2,6-dichlorobenzaldehyde 
• 64-17-5 ethanol 
• 88701-88-6 4-[(E)-2-(2,6-Dichloro-phenyl)-vinyl]-benzo[e][1,2,3]oxathiazine 2,2-dioxide 

Downstream Products

• 1418005-68-1 2-(2,6-dichlorophenyl)-2H-chromene 
• 141109-90-2 2-(2,4-dichlorophenyl)-4H-chromen-4-one 
• 88702-05-0 9b-[(E)-2-(2,6-Dichloro-phenyl)-vinyl]-1,3-diphenyl-1,9b-dihydro-5-oxa-4-thia-1,2,3a-triaza-cyclopenta[a]naphthalene 4,4-dioxide 
• 88702-01-6 4-[1,2-Dibromo-2-(2,6-dichloro-phenyl)-ethyl]-benzo[e][1,2,3]oxathiazine 2,2-dioxide 
• 88701-98-8 4-[3-(2,6-Dichloro-phenyl)-oxiranyl]-benzo[e][1,2,3]oxathiazine 2,2-dioxide 
• 88702-10-7 4-[(E)-2-(2,6-Dichloro-phenyl)-vinyl]-3,4-dihydro-benzo[e][1,2,3]oxathiazine 2,2-dioxide 
• 88701-93-3 C₁₆H₁₀Cl₃NO₅S 
• 88701-88-6 4-[(E)-2-(2,6-Dichloro-phenyl)-vinyl]-benzo[e][1,2,3]oxathiazine 2,2-dioxide 

Relevant academic research and scientific papers

X-ray characterization, Hirshfeld surface analysis, DFT calculations,in vitroandin silicolipoxygenase inhibition (LOX) studies of dichlorophenyl substituted 3-hydroxy-chromenones

This work reports the synthesis and X-ray characterization of three dichlorophenyl substituted 3-hydroxy-chromen-4-one derivatives,i.e., 2-(2,4-dichlorophenyl)-3-hydroxy-4H-chromen-4-one (1), 2-(2,3-dichlorophenyl)-3-hydroxy-4H-chromen-4-one (2), and 2-(2

Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor

Central neuromedin U 2 receptor (NMU2R) plays important roles in the regulation of food intake and body weight. Identification of NMU2R agonists may lead to the development of pharmaceutical agents to treat obesity. Based on the structure of rutin, a typi

Synthesis and cdc25B inhibitory activity evaluation of chalcones

A library of sixty-five chalcones was prepared for screening against the protein phosphatase, cdc25B. From this library, thirteen compounds were found having good inhibitory activity. Two compounds have excellent activity and can be used for the design of

A synthetic chalcone as a potent inducer of glutathione biosynthesis

Chalcones continue to attract considerable interest due to their anti-inflammatory and antiangiogenic properties. We recently reported the ability of 2′,5′-dihydroxychalcone (2′,5′-DHC) to induce both breast cancer resistance protein-mediated export of glutathione (GSH) and c-Jun N-terminal kinase-mediated increased intracellular GSH levels. Herein, we report a structure-activity relationship study of a series of 30 synthetic chalcone derivatives with hydroxyl, methoxyl, and halogen (F and Cl) substituents and their ability to increase intracellular GSH levels. This effect was drastically improved with one or two electrowithdrawing groups on phenyl ring B and up to three methoxyl and/or hydroxyl groups on phenyl ring A. The optimal structure, 2-chloro-4′,6′-dimethoxy-2′- hydroxychalcone, induced both a potent NF-E2-related factor 2-mediated transcriptional response and an increased formation of glutamate cysteine ligase holoenzyme, as shown using a human breast cancer cell line stably expressing a luciferase reporter gene driven by antioxidant response elements.

An unexpected rearrangement-hydration reaction sequence of 2H-chromenes to dihydrochalcones under catalysis of HAuCl4

2-Aryl-2H-chromenes in aqueous DCM medium under catalysis of HAuCl 4 are converted into 3-(2-hydroxyaryl)-1-arylpropan-1-ones through hydration-rearrangement reaction sequence in very good yield. The key step probably involves the [1,5] hydride shift followed by the hydrolysis under the reaction condition. The notable advantages of this method are operational simplicity and ease of isolation of products and also provide a pathway to convert the chalcone into DHCs with the transposition of carbonyl group. 2012 Elsevier Ltd. All rights reserved.

Novel (E)- and (Z)-2-styrylchromones from (E,E)-2′-hydroxycinnamylideneacetophenones - Xanthones from daylight photooxidative cyclization of (E)-2-styrylchromones

The oxidative cyclization of (E,E)-2′-hydroxycinnamylideneacetophenones 1a-e, and (E,E)-2′-benzyloxy-6′-hydroxycinnamylideneacetophenones 1i-1 with DMSO/ iodine, gave (E)-2-styrylchromones 3a-e,i-1. However, in the case of (E,E)-γ-alkyl-2′-hydroxycinnamyl

Synthesis of 4-Styryl-1,2,3-benzoxathiazine 2,2-Dioxides, Naphth-1,2,3-oxathiazine 2,2-dioxide and 1,3-Dipolar Cycloaddition of 1,3-Diphenylnitrilimine to 4-Styryl-1,2,3-benzoxathiazine 2,2-Dioxides

4-Styryl-1,2,3-benzoxathiazine 2,2-dioxide (4a-e) have been synthesized by the reaction of chlorosulphonyl isocyanate with 2'-hydroxychalcone (1a-e). 2-Hydroxy-1-napthaldehyde reacts with chlorosulphonyl isocyanate to give naphth-oxathiazine 2,2-dioxide (9).The 1,3-dipolar cycloaddition of 1,3-diphenylnitrilimine to 4a-e gives the hitherto unreported heterocyclic system (14)