1412418-47-3Relevant articles and documents
BENZENESULFONAMIDE DERIVATIVES AND USES THEREOF
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, (2021/02/12)
Provided herein are benzenesulfonamide derivatives having Formula (III), pharmaceutical compositions comprising said compounds, and method for using said compounds for disrupting proteins/polypeptides, protein/polypeptide function, and for the treatment of diseases through the disruption of proteins or polypeptides involved in the etiology of the disease. Said compounds comprise fluorinated benzene sulfonamide structures.
Catalytic Azido-Hydrazination of Alkenes Enabled by Visible Light: Mechanistic Studies and Synthetic Applications
Wang, Peng,Luo, Yunxuan,Zhu, Songsong,Lu, Dengfu,Gong, Yuefa
, p. 5565 - 5575 (2019/11/14)
A visible-light-enabled catalytic intermolecular azido-hydrazination method for unactivated alkenes is developed via an orderly radical addition sequence. This transformation features metal-free and redox-neutral conditions and is applicable to a wide range of alkenes with commercially available reagents. Mechanistic and kinetic studies reveal that the efficient generation of azide radical enabled by fluorenone under visible-light is critical to this methodology. The β-azido alkyl hydrazines prepared with this reaction can be conveniently derived to valuable synthetic building blocks, and one of the products has been successfully applied in the total synthesis of (±)-ibrutinib, which is used to treat B cell cancers. (Figure presented.).
KINASE INHIBITORS
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Paragraph 0433, (2014/11/11)
Provided herein are kinase inhibiting compounds and methods of using the same.