129888-60-4

Basic information

• Product Name: N-BOC-3-MESYLOXYPIPERIDINE
• Synonyms: tert-Butyl 3-Methylsulfonyloxypiperidin-1-carboxylate;tert-Butyl 3-Methylsulfonyloxypiperidine-1-carboxylate;3-(Methylsulfonyloxy)piperidine-1-carboxylic acid tert-butyl ester;1-Piperidinecarboxylic acid, 3-[(Methylsulfonyl)oxy]-, 1,1-diMethylethyl ester;tert-Butyl 3-((methylsulfonyl);1-Boc-3-methanesulphonyloxypiperidine;N-BOC-3-(Methylsulfonyloxy)piperidine
• CAS NO: 129888-60-4
• Molecular Formula: C₁₁H₂₁NO₅S
• Molecular Weight: 279.36
• Mol File: 129888-60-4.mol
• Article Data: 27

Chemical Properties

• Boiling Point: 407.2 °C at 760 mmHg
• Flash Point: 200.1 °C
• Appearance: /
• Density: 1.22 g/cm³
• Vapor Pressure: 7.69E-07mmHg at 25°C
• Refractive Index: 1.5
• Storage Temp.: 2-8°C
• PKA: -3.34±0.40(Predicted)
• CAS DataBase Reference: N-BOC-3-MESYLOXYPIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-BOC-3-MESYLOXYPIPERIDINE(129888-60-4)
• EPA Substance Registry System: N-BOC-3-MESYLOXYPIPERIDINE(129888-60-4)

Safety Data

• Hazardous Substances Data: 129888-60-4(Hazardous Substances Data)

Usage

General Description

N-BOC-3-MESYLOXYPIPERIDINE is a chemical compound that belongs to the piperidine family. Its molecular structure consists of a piperidine ring with a BOC (tert-butoxycarbonyl) protective group at the nitrogen atom and a mesyloxy group attached to the piperidine ring. The BOC protective group is commonly used in organic synthesis to protect amines from unwanted reactions, while the mesyloxy group is a leaving group that can be easily substituted with other functional groups. N-BOC-3-MESYLOXYPIPERIDINE has applications in organic chemistry as a building block for the synthesis of various pharmaceuticals, agrochemicals, and other fine chemicals. Additionally, N-BOC-3-MESYLOXYPIPERIDINE is often used as a reagent in the synthesis of complex molecules due to its versatile reactivity and ease of manipulation.

InChI:InChI=1/C11H21NO5S/c1-11(2,3)16-10(13)12-7-5-6-9(8-12)17-18(4,14)15/h9H,5-8H2,1-4H3

Upstream product

• 85275-45-2 N-tert-butoxycarbonyl-3-piperidinol 
• 124-63-0 methanesulfonyl chloride 
• 6859-99-0 3-hydroxypiperazine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 7143-01-3 Methanesulfonic anhydride 
• 121-44-8 triethylamine 
• 98977-36-7 3-oxo-piperidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 1017798-33-2 tert-butyl 3-(acetylsulfanyl)piperidine-1-carboxylate 
• 1374241-37-8 1-(3-(4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-2-((3,5-dichlorophenyl)amino)ethanone 
• 1412418-48-4 (2E)-2-[(E)-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]carbonyl]-3-cyclopropylprop-2-enenitrile 
• 1412418-65-5 _{(R)-2-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carbonyl)-4,4-dimethylpent-2-enenitrile} 
• 1412418-06-4 3-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-3-oxopropanenitrile 
• 1412418-08-6 2-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carbonyl)-4,4-dimethylpent-2-enenitrile 
• 131667-57-7 tert-butyl 1,2,3,4-tetrahydro-1-pyridinecarboxylate 
• 85838-94-4 N-Boc-1,2,3,6-tetrahydropyridine 

Relevant articles and documents

Compound used as RET kinase inhibitor and application thereof

The invention relates to a compound used as an RET kinase inhibitor and application thereof, wherein the compound has a structure as shown in a formula F, has good inhibition capability on RET kinase, and has good pharmacodynamic and pharmacokinetic performance and lower toxic and side effects.

SMARCA DEGRADERS AND USES THEREOF

The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same for the modulation of one or more SWI/SNF-related matrix associated actin dependent regulator of chromatin subfamily A (SMARCA) and/or polybromo-1 (PB-1) protein via ubiqitination and/or degradation by compounds. The compounds are bifunctional molecules that link a cereblon-binding moiety to a ligand that binds SMARCA and/or PB1 proteins.

Discovery of (R)-5-((5-(1-methyl-1H-pyrazol-4-yl)-4-(methylamino)pyrimidin-2-yl)amino)-3-(piperidin-3-yloxy)picolinonitrile, a novel CHK1 inhibitor for hematologic malignancies

Through virtual screening, we identified the lead compound MCL1020, which exhibited modest CHK1 inhibitory activity. Then a series of 5-(pyrimidin-2-ylamino)picolinonitrile derivatives as CHK1 inhibitors were discovered by further rational optimization. One promising molecule, (R)-17, whose potency was one of the best, had an IC50 of 0.4 nM with remarkable selectivity (>4300-fold CHK1 vs. CHK2). Compound (R)-17 effectively inhibited the growth of malignant hematopathy cell lines especially Z-138 (IC50: 0.013 μM) and displayed low affinity for hERG (IC50 > 40 μM). Moreover, (R)-17 significantly suppressed the tumor growth in Z-138 cell inoculated xenograft model (20 mg/kg I.V., TGI = 90.29%) as a single agent with body weight unaffected. Taken together, our data demonstrated compound (R)-17 could be a promising drug candidate for the treatment of hematologic malignancies.